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Related Concept Videos

Human Genetics01:28

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
Brain Imaging01:14

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Neural Regulation01:37

Neural Regulation

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Related Experiment Video

Updated: Jun 16, 2026

Induction of an Isoelectric Brain State to Investigate the Impact of Endogenous Synaptic Activity on Neuronal Excitability In Vivo
10:19

Induction of an Isoelectric Brain State to Investigate the Impact of Endogenous Synaptic Activity on Neuronal Excitability In Vivo

Published on: March 31, 2016

Genetic control over the resting brain.

D C Glahn1, A M Winkler, P Kochunov

  • 1Olin Neuropsychiatry Research Center, Institute of Living, Hartford Hospital, Hartford, CT 06106, USA. david.glahn@yale.edu

Proceedings of the National Academy of Sciences of the United States of America
|February 6, 2010
PubMed
Summary
This summary is machine-generated.

Genetic factors significantly influence the default-mode network

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Area of Science:

  • Neuroscience
  • Genetics
  • Brain Imaging

Background:

  • The default-mode network (DMN) is a crucial brain network for resting-state activity.
  • Altered DMN connectivity is linked to various neurological and psychiatric disorders.
  • The genetic underpinnings of DMN regulation are not fully understood.

Purpose of the Study:

  • To quantify the heritability of functional connectivity within the default-mode network.
  • To investigate the relationship between genetic influences on DMN functional connectivity and gray-matter density.
  • To identify specific genetic factors contributing to DMN connectivity patterns.

Main Methods:

  • Analysis of functional connectivity patterns in 333 individuals across 29 extended pedigrees.
  • Estimation of heritability for default-mode functional connectivity.
  • Examination of genetic correlations between different brain regions within the DMN.

Main Results:

  • Heritability of default-mode functional connectivity was estimated at 0.424 +/- 0.17 (P = 0.0046).
  • Genetic factors influencing DMN functional connectivity appear distinct from those affecting gray-matter density.
  • Shared genetic factors influence connectivity across multiple DMN regions, including the left parahippocampal, posterior cingulate/precuneus, medial prefrontal cortex, and right cerebellum.

Conclusions:

  • Default-mode functional connectivity is substantially influenced by genetic factors.
  • These genetic influences are independent of anatomical variation and specific network regions.
  • The findings support the consideration of DMN functional connectivity measures as potential endophenotypes for psychiatric and neurological illnesses.