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Updated: Jul 17, 2026

A Preclinical Model of Exertional Heat Stroke in Mice
Published on: July 1, 2021
Liver failure occurring as a component of exertional heatstroke
T Hassanein1, J A Perper, L Tepperman
1Department of Medicine, University of Pittsburgh, Pennsylvania.
Abstract:
An unusual case of an exertional heatstroke in a healthy 25-year-old man is presented. Initially, the patient was deeply comatose and developed severe rhabdomyolysis and massive hepatic necrosis. Subsequently, he received a liver transplant with remarkable improvement in his mental status, although the rhabdomyolysis continued. The patient died 41 days after the transplant due to a complicating infection. Providing that infections can be effectively controlled, liver transplants might be a promising therapeutic alternative for the few patients who survive the initial neurological consequences of this unusual event.
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