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Real-time imaging for dose evaluation during antiproton irradiation.

I Kantemiris1, A Angelopoulos, N Bassler

  • 1Nuclear and Particle Physics Section, Physics Department, University of Athens, Panepistimioupolis, Ilisia, 157 71 Athens, Greece. ikantem@phys.uoa.gr

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|February 6, 2010
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Real-time monitoring of particle beams in radiotherapy using antiproton annihilation can detect dose errors. Detecting charged pions allows precise, millimeter-level localization of the target volume during treatment.

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Area of Science:

  • Medical Physics
  • Particle Physics
  • Radiotherapy Technology

Background:

  • Online monitoring of particle beam stopping distributions in radiotherapy is crucial for early detection of dose deposition errors.
  • Improving radiotherapy quality relies on real-time error detection during treatment sessions.
  • Antiproton annihilation produces detectable secondary particles suitable for real-time monitoring.

Purpose of the Study:

  • To investigate the feasibility of real-time imaging using charged pions from antiproton irradiation.
  • To assess the precision of target volume localization during antiproton therapy.

Main Methods:

  • Monte Carlo calculations were performed to simulate antiproton irradiation of biological targets.
  • Detection of charged pions (pi+/-) produced during irradiation was simulated.
  • A simplified treatment plan in a water phantom was modeled.

Main Results:

  • The study demonstrates the potential for real-time imaging by detecting charged pions.
  • Simulations show that the position and size of the planned target volume can be located with approximately 1 mm precision.
  • This method allows for precise localization of the treatment area.

Conclusions:

  • Detecting charged pions from antiproton annihilation offers a viable method for online monitoring in radiotherapy.
  • This technique can significantly enhance the safety and quality of particle beam therapy.
  • Real-time, millimeter-precision localization of the target volume is achievable.