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Is pentraxin 3 involved in obesity-induced decrease in arterial distensibility?

Asako Miyaki1, Seiji Maeda, Mutsuko Yoshizawa

  • 1Division of Sports Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan.

Journal of Atherosclerosis and Thrombosis
|February 6, 2010
PubMed
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Obese men exhibit reduced arterial distensibility and elevated Pentraxin 3 (PTX3) levels. Higher PTX3 may contribute to decreased arterial function in obesity, a risk factor for cardiovascular disease.

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Area of Science:

  • Cardiovascular Science
  • Metabolic Health
  • Inflammation Biology

Background:

  • Obesity is a significant risk factor for cardiovascular morbidity and mortality.
  • Decreased central arterial distensibility is an independent risk factor for cardiovascular disease (CVD).
  • The mechanisms linking obesity to reduced arterial distensibility remain unclear, though Pentraxin 3 (PTX3) is implicated in vascular inflammation.

Purpose of the Study:

  • To investigate plasma Pentraxin 3 (PTX3) concentrations in obese subjects.
  • To assess arterial distensibility in obese individuals.
  • To explore the relationship between PTX3 levels and arterial distensibility in obesity.

Main Methods:

  • Compared 11 obese men (BMI 32±1 kg/m²) with 14 non-obese men (BMI 26±1 kg/m²).
  • Measured arterial compliance and beta-stiffness index of the common carotid artery.
  • Quantified plasma PTX3 concentrations.

Main Results:

  • Obese men demonstrated significantly lower arterial compliance compared to non-obese men.
  • The beta-stiffness index was significantly higher in obese men.
  • Plasma PTX3 concentrations were markedly elevated in obese men.

Conclusions:

  • Obese men exhibit diminished arterial distensibility and increased circulating PTX3 levels.
  • Elevated PTX3 concentrations and reduced arterial distensibility coexist in obese men.
  • High PTX3 levels may play a role in the obesity-associated decrease in arterial distensibility.