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Adipocytes IGFBP-2 expression in prepubertal obese children.

Maffeis Claudio1, Ficial Benjamim, Bonadonna Riccardo

  • 1Regional Centre for Juvenile Diabetes, Section of Obesity and Clinical Nutrition, Department of Mother and Child, Biology-Genetics, University of Verona, Verona, Italy. claudio.maffeis@univr.it

Obesity (Silver Spring, Md.)
|February 6, 2010
PubMed
Summary

Insulin-like growth factor-binding protein-2 (IGFBP-2) is expressed by fat cells in obese children and increases with adiposity. This local IGFBP-2 expression may help limit further fat gain, independent of insulin sensitivity.

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Published on: June 3, 2016

Area of Science:

  • Endocrinology
  • Metabolic Syndrome
  • Adipose Tissue Biology

Background:

  • Obesity is linked to metabolic dysfunction, including insulin resistance.
  • Insulin-like growth factor-binding protein-2 (IGFBP-2) plays a role in metabolic regulation.
  • Understanding local IGFBP-2 expression in adipocytes is crucial for metabolic research.

Purpose of the Study:

  • To measure IGFBP-2 expression in abdominal subcutaneous adipocytes of obese children.
  • To investigate the relationship between IGFBP-2 expression, circulating IGFBP-2, obesity, and insulin sensitivity.
  • To explore potential local mechanisms of adipocyte function in obesity.

Main Methods:

  • Recruited 38 obese children.
  • Assessed insulin sensitivity using intravenous glucose tolerance tests.
  • Measured body composition via dual-energy X-ray absorptiometry.
  • Quantified IGFBP-2 mRNA in adipose tissue biopsies using real-time PCR.
  • Measured serum levels of IGF-I, IGFBP-2, adiponectin, and leptin.

Main Results:

  • Circulating IGFBP-2 positively correlated with insulin sensitivity.
  • Adipocyte IGFBP-2 expression correlated with fat mass percentage, insulin sensitivity, free IGF-I, and leptin.
  • IGFBP-2 expression increased with adiposity, independent of insulin sensitivity.
  • No significant correlation was found between IGFBP-2 expression and circulating IGFBP-2 levels.

Conclusions:

  • Circulating IGFBP-2 is associated with improved insulin sensitivity.
  • Subcutaneous abdominal adipocytes in obese children express IGFBP-2.
  • IGFBP-2 expression in adipocytes increases with adiposity, suggesting a local regulatory role.
  • Adipocyte IGFBP-2 may act as a mechanism to limit excessive fat accumulation.