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Cefpodoxime proxetil concentrations in head and neck tissues
H M Theopold1, C Matthias, D Adam
1Fakultät der LMU München, Germany.
Infection
|January 1, 1991
Summary
A single oral dose of cefpodoxime proxetil achieved therapeutic concentrations in head and neck tissues. These levels exceeded the minimum inhibitory concentrations for common respiratory pathogens, suggesting efficacy for surgical prophylaxis.
Area of Science:
- Pharmacology
- Surgical Prophylaxis
- Head and Neck Surgery
Background:
- Cefpodoxime proxetil is an oral cephalosporin antibiotic.
- Effective antibiotic prophylaxis is crucial in head and neck surgeries to prevent infections.
Purpose of the Study:
- To determine the serum and tissue concentrations of cefpodoxime proxetil in patients undergoing head and neck surgery.
- To evaluate if achieved concentrations are sufficient to inhibit common pathogens.
Main Methods:
- 30 patients received a single 200 mg oral dose of cefpodoxime proxetil 3-6 hours before surgery.
- Serum and various head and neck tissue samples were collected during surgery.
- Cefpodoxime concentrations were quantified using bioassay.
Main Results:
- Serum concentrations ranged from 0.72 mg/l to 3.34 mg/l.
- Tissue concentrations varied from 0.15 mg/l (bone) to 1.94 mg/l (concha).
- Achieved tissue concentrations were generally higher than MIC90 values for key pathogens.
Conclusions:
- Cefpodoxime proxetil demonstrates favorable pharmacokinetic properties in head and neck tissues.
- The drug achieves concentrations likely effective against common pathogens in the region.
- Supports the use of cefpodoxime proxetil for surgical prophylaxis in head and neck procedures.