Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cardiocirculatory arrest with hypothermia. Experimental study.

A Puca1, R F Spetzler, J M Zabramski

  • 1Istituto di Neurochirurgia, Università Cattolica, Roma.

Italian Journal of Neurological Sciences
|February 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Chemically Modified Variants of Fenofibrate with Antiglioblastoma Potential.

Translational oncology·2019
Same author

Retractorless surgery for intracranial aneurysms.

Journal of neurosurgical sciences·2015
Same author

Fenofibrate subcellular distribution as a rationale for the intracranial delivery through biodegradable carrier.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society·2015
Same author

Diagnosis and management of dural arteriovenous fistulas: a 10 years single-center experience.

Clinical neurology and neurosurgery·2014
Same author

Indocyanine green video-angiography in neurosurgery: a glance beyond vascular applications.

Clinical neurology and neurosurgery·2014
Same author

Endovascular management of distal ACA aneurysms: single-institution clinical experience in 22 consecutive patients and literature review.

AJNR. American journal of neuroradiology·2013

Complete cardiocirculatory arrest under hypothermia can aid complex brain surgery. A 45-minute arrest proved safe in baboons, while 90 minutes risked complications, manageable with heparinization.

Area of Science:

  • Neurosurgery
  • Cardiovascular Surgery
  • Hypothermia Research

Background:

  • Complex intracranial malformations pose surgical challenges.
  • Cardiocirculatory arrest under hypothermia is a potential surgical aid.
  • Optimizing this procedure requires understanding safe arrest durations and protective measures.

Purpose of the Study:

  • To evaluate the safety and efficacy of cardiocirculatory arrest under hypothermia for complex intracranial malformations.
  • To determine the optimal duration of circulatory arrest at a specific hypothermia level.
  • To assess the role of barbiturate brain protection in this surgical context.

Main Methods:

  • An experimental study was conducted on 11 baboons.
  • Animals underwent complete cardiocirculatory arrest at 12 degrees C brain temperature for either 45 or 90 minutes.

Related Experiment Videos

  • Post-procedure assessment included clinical, neuroradiological, and necropsy examinations.

    • Main Results:

    • All 4 animals with 45 minutes of arrest recovered well clinically.
    • Three out of seven animals subjected to 90 minutes of arrest experienced thromboembolic complications.
    • Strict heparinization successfully mitigated complications in the final two animals undergoing 90-minute arrest.

    Conclusions:

    • Forty-five minutes of cardiocirculatory arrest at 12 degrees C appears safe for baboons.
    • Ninety minutes of arrest carries a risk of thromboembolic complications, which can be managed with heparinization.
    • Findings suggest potential improvements for the clinical application of this surgical technique.