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Updated: Jun 16, 2026

Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells
Published on: February 21, 2018
Granulocyte colony stimulating factor in neonatal alloimmune neutropenia: a possible association with induced
Christina Wiedl1, Andrew W Walter
1Department of Pediatric Hematology/Oncology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA. christina_wiedl@urmc.rochester.edu
Abstract:
Neonatal alloimmune neutropenia (NAIN) is a rare cause of congenital neutropenia seen in <1% of births. Significant morbidity, usually infections, may result from this disease. The pathophysiology of NAIN, mediated by maternal antibodies crossing the placenta to destroy fetal cells expressing paternal antigens, is similar to that of neonatal alloimmune thrombocytopenia, as well as Rh/ABO hemolytic disease of the newborn. The use of high-dose granulocyte colony stimulating factor in patients with NAIN may cause a reversible thrombocytopenia in some patients.
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