Related Experiment Video
Updated: Jun 16, 2026
13:56
Robot Assisted Distal Pancreatectomy with Celiac Axis Resection (DP-CAR) for Pancreatic Cancer: Surgical Planning and Technique
Published on: August 14, 2021
Endoscopic ultrasound-guided celiac plexus neurolysis using a reverse phase polymer
Keith L Obstein1, Fernanda P Martins, Gloria Fernández-Esparrach
1Gastroenterology Division, Brigham and Women's Hospital, Boston, MA 02115, United States.
World Journal of Gastroenterology
|February 6, 2010
Summary
Endoscopic ultrasound (EUS)-guided celiac plexus neurolysis (CPN) using a poloxamer gel was feasible in pigs. This novel technique precisely delivered the neurolytic agent to the celiac plexus.
Area of Science:
- Gastroenterology
- Interventional Endoscopy
- Pain Management
Background:
- Celiac plexus neurolysis (CPN) is used to manage abdominal pain.
- Endoscopic ultrasound (EUS)-guided procedures offer enhanced visualization for targeted interventions.
- Poloxamers are novel polymers with potential applications in drug delivery.
Purpose of the Study:
- To evaluate the feasibility of EUS-guided CPN.
- To assess the delivery precision of a poloxamer-based neurolytic agent.
Main Methods:
- A prospective study involving six Yorkshire pigs undergoing EUS-guided CPN.
- Group 1: Injection of Lidocaine with methylene blue.
- Group 2: Injection of Lidocaine with blue-colored poloxamer (PS137-25).
- Necropsy and examination for agent distribution.
Main Results:
- EUS-guided CPN was technically feasible in all pigs without immediate complications.
- Methylene blue dispersed widely in the peritoneal and retroperitoneal cavities (Group 1).
- Poloxamer gel localized precisely to the celiac plexus region (Group 2).
Conclusions:
- EUS-guided CPN using a poloxamer in a porcine model is technically feasible.
- Poloxamer demonstrates precise delivery of the neurolytic agent to the celiac plexus.
- This technique shows promise for targeted pain management interventions.
