Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Biofilms01:29

Biofilms

Biofilms are complex communities of microorganisms encased in a self-produced extracellular polysaccharide matrix attached to surfaces. These microbial consortia can include single or multiple species, providing enhanced survival benefits by forming organized, multilayered structures.The formation of biofilms occurs through four key stages: attachment, colonization, development, and dispersal.During attachment, free-swimming planktonic cells adhere to a surface, often facilitated by...
Bacterial Signaling01:30

Bacterial Signaling

Bacterial signaling can occur within bacteria (intracellular) or between bacteria (intercellular). At times, a group of bacteria behaves like a community. To achieve this, they engage in quorum sensing, the perception of higher cell density that causes changes in gene expression. Quorum sensing involves both extracellular and intracellular signaling. The signaling cascade starts with a molecule called an autoinducer (AI). Individual bacteria produce AIs that move out of the bacterial cell...
Microbial Mats01:25

Microbial Mats

Microbial communities forming biofilms and mats represent complex, spatially structured ecosystems where metabolic processes are stratified according to light, oxygen, and nutrient gradients. Biofilms are initial colonization stages, only a few millimeters thick, while mature microbial mats can reach centimeter-scale thickness and display intricate vertical organization. Their structural and functional heterogeneity allows microorganisms to occupy distinct ecological niches within a few...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparison and development of machine learning tools for the prediction of chronic obstructive pulmonary disease in the Chinese population.

Journal of translational medicine·2020
Same author

Low-Energy Shockwave Treatment Promotes Endothelial Progenitor Cell Homing to the Stenotic Pig Kidney.

Cell transplantation·2020
Same author

Transplanted senescent renal scattered tubular-like cells induce injury in the mouse kidney.

American journal of physiology. Renal physiology·2020
Same author

Mesenchymal Stem Cell-Derived Extracellular Vesicles Induce Regulatory T Cells to Ameliorate Chronic Kidney Injury.

Hypertension (Dallas, Tex. : 1979)·2020
Same author

miR-34a regulates adipogenesis in porcine intramuscular adipocytes by targeting ACSL4.

BMC genetics·2020
Same author

Design and synthesis of novel 2-arylbenzimidazoles as selective mutant isocitrate dehydrogenase 2 R140Q inhibitors.

Bioorganic & medicinal chemistry letters·2020

Related Experiment Video

Updated: Jun 16, 2026

Development of a Polymicrobial Colony Biofilm Model to Test Antimicrobials in Cystic Fibrosis
07:16

Development of a Polymicrobial Colony Biofilm Model to Test Antimicrobials in Cystic Fibrosis

Published on: September 20, 2024

[Bacterial biofilms and chronic osteomyelitis].

Hui Tang1, Yongqing Xu

  • 1Hospital of Chengdu Military Command, Kunming Yunnan, 650032, PR China.

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi = Zhongguo Xiufu Chongjian Waike Zazhi = Chinese Journal of Reparative and Reconstructive Surgery
|February 9, 2010
PubMed
Summary

Bacterial biofilms (BBF) significantly complicate chronic osteomyelitis treatment by conferring antimicrobial resistance. Debridement remains the most effective strategy against these resilient biofilms.

More Related Videos

A Platform of Anti-biofilm Assays Suited to the Exploration of Natural Compound Libraries
09:39

A Platform of Anti-biofilm Assays Suited to the Exploration of Natural Compound Libraries

Published on: December 27, 2016

Related Experiment Videos

Last Updated: Jun 16, 2026

Development of a Polymicrobial Colony Biofilm Model to Test Antimicrobials in Cystic Fibrosis
07:16

Development of a Polymicrobial Colony Biofilm Model to Test Antimicrobials in Cystic Fibrosis

Published on: September 20, 2024

A Platform of Anti-biofilm Assays Suited to the Exploration of Natural Compound Libraries
09:39

A Platform of Anti-biofilm Assays Suited to the Exploration of Natural Compound Libraries

Published on: December 27, 2016

Area of Science:

  • Microbiology
  • Orthopedic Surgery
  • Infectious Diseases

Context:

  • Chronic osteomyelitis presents significant diagnostic and therapeutic challenges.
  • Bacterial biofilms (BBF) are increasingly recognized as a critical factor in treatment failure and recurrence.
  • Understanding BBF formation is crucial for developing effective therapeutic strategies.

Purpose:

  • To review the impact of bacterial biofilms on chronic osteomyelitis.
  • To discuss current treatment modalities for biofilm-associated chronic osteomyelitis.

Summary:

  • Bacterial biofilms contribute to the difficulty in treating chronic osteomyelitis due to enhanced bacterial resistance to antimicrobials.
  • Biofilms form on necrotic tissue and dead bone, protecting bacteria through adhesion, development, and maturation processes.
  • Staphylococcus species, common pathogens, exhibit unique biofilm-forming characteristics that influence treatment.

Impact:

  • Highlights debridement as the primary effective method for combating biofilms in chronic osteomyelitis.
  • Emphasizes the need for targeted therapeutic programs addressing specific biofilm characteristics.
  • Informs clinical practice and future research directions for managing this challenging infection.