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Updated: Jun 16, 2026

High-throughput Synthesis of Carbohydrates and Functionalization of Polyanhydride Nanoparticles
Published on: July 6, 2012
Glycodynamers: dynamic polymers bearing oligosaccharides residues--generation, structure, physicochemical, component
Yves Ruff1, Eric Buhler, Sauveur-Jean Candau
1Laboratoire de Chimie Supramoléculaire, ISIS, Université de Strasbourg, 67000 Strasbourg, France.
Abstract:
Dynamic glycopolymers have been generated by polycondensation through acylhydrazone formation between components bearing lateral bioactive oligosaccharide chains. They have been characterized as bottlebrush type by cryo-TEM and SANS studies. They present remarkable fluorescence properties whose emission wavelengths depend on the constitution of the polymer and are tunable by constitutional modification through exchange/incorporation of components, thus also demonstrating their dynamic character. Constitution-dependent binding of these glycodynamers to a lectin, peanut agglutinin, has been demonstrated.
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