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Related Experiment Videos

Plasma leucocyte elastase concentrations in smokers.

C R Hind1, H Joyce, G A Tennent

  • 1Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London.

Journal of Clinical Pathology
|March 1, 1991
PubMed
Summary
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Cigarette smoking is linked to higher plasma leucocyte elastase concentrations and faster lung function decline (FEV1). Smokers show increased elastase release, suggesting a role in pulmonary damage.

Area of Science:

  • Pulmonary Medicine
  • Biochemistry

Background:

  • Cigarette smoking is a major risk factor for lung diseases.
  • Leucocyte elastase is implicated in tissue damage, but its role in smokers is not fully understood.

Purpose of the Study:

  • To investigate the relationship between cigarette smoking, plasma leucocyte elastase, leucocyte count, and lung function (FEV1).

Main Methods:

  • Examined 148 men (current smokers, ex-smokers, never-smokers) in a long-term survey.
  • Measured plasma leucocyte elastase concentration, peripheral leucocyte count, and forced expiratory volume in 1 second (FEV1).

Main Results:

  • Smokers had significantly higher plasma leucocyte elastase concentrations than non-smokers.
  • Smokers exhibited lower mean FEV1 and a faster annual decline in FEV1.

Related Experiment Videos

  • No association was found between plasma elastase and leucocyte count or FEV1 decline.

    • Conclusions:

    • Male smokers show increased in vivo elastase release from neutrophils, independent of acute infection.
    • Elevated leucocyte elastase may contribute to pulmonary tissue damage in smokers.
    • Further research into the mechanisms of increased plasma elastase is warranted.