Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Allergic Reactions02:06

Allergic Reactions

Overview
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Asthma III: Clinical Manifestations01:13

Asthma III: Clinical Manifestations

Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pioneers in Dermatology and Venereology: an interview with Jon Hanifin, M.D.

Journal of the European Academy of Dermatology and Venereology : JEADV·2019
Same author

Initial validation of the Burden of Disease in Atopic Eczema instrument, a quality-of-life measure for adult atopic dermatitis.

The British journal of dermatology·2018
Same author

Altered composition of epidermal lipids correlates with Staphylococcus aureus colonization status in atopic dermatitis.

The British journal of dermatology·2017
Same author

What the Eczema Area and Severity Index score tells us about the severity of atopic dermatitis: an interpretability study.

The British journal of dermatology·2015
Same author

Inadequate response to ustekinumab in atopic dermatitis - a report of two patients.

Journal of the European Academy of Dermatology and Venereology : JEADV·2014
Same author

Report from the third international consensus meeting to harmonise core outcome measures for atopic eczema/dermatitis clinical trials (HOME).

The British journal of dermatology·2014

Related Experiment Video

Updated: May 11, 2026

A Reversible, Non-invasive Method for Airway Resistance Measurements and Bronchoalveolar Lavage Fluid Sampling in Mice
09:58

A Reversible, Non-invasive Method for Airway Resistance Measurements and Bronchoalveolar Lavage Fluid Sampling in Mice

Published on: April 14, 2010

Airway responsiveness in atopic dermatitis.

A F Barker1, C A Hirshman, R D'Silva

  • 1Department of Internal Medicine, Oregon Health Services University, Portland.

The Journal of Allergy and Clinical Immunology
|April 1, 1991
PubMed
Summary

Patients with atopic dermatitis (AD) frequently have hyperresponsive airways, indicated by positive methacholine challenge tests. This suggests shared mechanisms between skin and airway conditions in AD.

More Related Videos

Murine Model of Allergen Induced Asthma
08:05

Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber
08:47

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

Published on: March 3, 2023

Related Experiment Videos

Last Updated: May 11, 2026

A Reversible, Non-invasive Method for Airway Resistance Measurements and Bronchoalveolar Lavage Fluid Sampling in Mice
09:58

A Reversible, Non-invasive Method for Airway Resistance Measurements and Bronchoalveolar Lavage Fluid Sampling in Mice

Published on: April 14, 2010

Murine Model of Allergen Induced Asthma
08:05

Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber
08:47

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

Published on: March 3, 2023

Area of Science:

  • Pulmonology
  • Dermatology
  • Clinical Immunology

Background:

  • Atopic dermatitis (AD) is a chronic inflammatory skin condition.
  • The relationship between AD and respiratory conditions like asthma is recognized.
  • Underlying mechanisms linking skin and airway physiology in AD require further investigation.

Purpose of the Study:

  • To investigate the prevalence of airway hyperresponsiveness in patients with atopic dermatitis.
  • To compare airway hyperresponsiveness in atopic dermatitis patients with those having psoriasis.
  • To explore potential shared pathophysiological mechanisms between AD and airway disorders.

Main Methods:

  • Screening of patients with atopic dermatitis and psoriasis using questionnaires and spirometry.
  • Exclusion criteria included smoking, hay fever, and pre-existing respiratory disorders.
  • Administration of methacholine challenge tests to assess airway responsiveness.

Main Results:

  • Seven out of twelve (58%) patients with atopic dermatitis exhibited a positive methacholine challenge test.
  • None of the eight patients with psoriasis showed a positive methacholine challenge.
  • A significant proportion of AD patients, after exclusions, demonstrated airway hyperresponsiveness.

Conclusions:

  • Airway hyperresponsiveness is a common finding in patients diagnosed with atopic dermatitis.
  • Shared physiological or pharmacological mechanisms may underlie both cutaneous abnormalities in AD and airway hyperresponsiveness.
  • Further research is warranted to elucidate the connection between atopic dermatitis and respiratory system involvement.