Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Pathophysiology of Vomiting

Pathophysiology of Vomiting

Vomiting is a complex physiological response to expel harmful or irritating substances from the body. It's a defensive mechanism triggered by stimuli like poisons, microbial toxins, cytotoxic drugs, and mechanical abdominal distension. The process is centrally coordinated by the vomiting (or emetic) center located in the medulla of the brainstem. This area, rich in muscarinic M1, histamine H1, neurokinin 1 (NK1), and serotonin 5-HT3 receptors, coordinates the act of vomiting through interaction...

Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists

Chemotherapy-Induced Nausea and Vomiting: 5-HT₃ Receptor Antagonists

5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...

Acute Pancreatitis II: Clinical Manifestations and Management

Acute Pancreatitis II: Clinical Manifestations and Management

Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...

Prevention of Further Absorption of Poison

Prevention of Further Absorption of Poison

In cases of acute poisoning, the primary objective is to prevent further absorption of the toxic substance into the body. Immediate interventions using various decontamination techniques targeting the gastrointestinal (GI) tract can achieve this. Decontamination is crucial to prevent poison from entering the systemic circulation, which involves washing affected areas with water and mild soap and removing contaminated clothing. Once external decontamination is done, attention must be turned to...

Acute Pancreatitis I: Introduction

Acute Pancreatitis I: Introduction

Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:

Acute Pancreatitis I: Introduction

Acute Pancreatitis I: Introduction

Acute pancreatitis is the sudden inflammation of the pancreas caused by the early activation of digestive enzymes, leading to the autodigestion of pancreatic tissue. This results in local inflammation and, in severe cases, systemic complications.EtiologyUnderstanding the underlying causes is crucial, as identifying the etiology guides treatment and anticipates complications. Acute pancreatitis can be triggered by various factors, typically grouped into the following clinical categories.Biliary...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Retrospective study on diagnostic yield and medical impact of diagnostic imaging in dogs with immune-mediated haemolytic anaemia in Belgium.

The Journal of small animal practice·2026

Same author

Protein-level profiling of TIGIT axis components in human PDAC reveals immune-suppressive expression patterns.

Cancer immunology, immunotherapy : CII·2026

Same author

Inducing emesis in Australian dogs and cats: agents, adverse effects and antiemetic administration.

Australian veterinary journal·2025

Same author

Using veterinary health records at scale to investigate ageing dogs and their common issues in primary care.

The Journal of small animal practice·2024

Same author

Investigations into disease associations with feline immunodeficiency virus (FIV) infection in lions (Panthera leo) in Australia: a case-control study.

Australian veterinary journal·2024

Same author

Antiviral therapy in cats progressively infected with feline leukaemia virus: lessons from a series of 18 consecutive cases from Australia.

Australian veterinary journal·2024

Search research articles

Related Experiment Video

Updated: Jun 16, 2026

Saline Lavage for Sampling of the Canine Nasal Immune Microenvironment

Saline Lavage for Sampling of the Canine Nasal Immune Microenvironment

Published on: December 27, 2024

Emesis in dogs: a review.

C Elwood¹, P Devauchelle, J Elliott

¹Davies Veterinary Specialists, Manor Farm Business Park, Higham Gobion, Hitchin, Hertfordshire SG5 3HR.

The Journal of Small Animal Practice

|February 9, 2010

Summary

This review examines the causes, consequences, and management of vomiting in dogs. It assesses current evidence on diagnostic methods and treatments, including anti-emetic drugs, for canine emesis.

More Related Videos

Operating Procedures of the Electrochemotherapy for Treatment of Tumor in Dogs and Cats

Operating Procedures of the Electrochemotherapy for Treatment of Tumor in Dogs and Cats

Published on: October 24, 2016

Ear Plaster Therapy as a Safe and Effective Treatment for Gestational Vomiting

Ear Plaster Therapy as a Safe and Effective Treatment for Gestational Vomiting

Published on: August 4, 2023

Related Experiment Videos

Last Updated: Jun 16, 2026

Saline Lavage for Sampling of the Canine Nasal Immune Microenvironment

Saline Lavage for Sampling of the Canine Nasal Immune Microenvironment

Published on: December 27, 2024

Operating Procedures of the Electrochemotherapy for Treatment of Tumor in Dogs and Cats

Operating Procedures of the Electrochemotherapy for Treatment of Tumor in Dogs and Cats

Published on: October 24, 2016

Ear Plaster Therapy as a Safe and Effective Treatment for Gestational Vomiting

Ear Plaster Therapy as a Safe and Effective Treatment for Gestational Vomiting

Published on: August 4, 2023

Area of Science:

Veterinary Medicine
Small Animal Practice
Clinical Research

Background:

Emesis (vomiting) is a frequent clinical sign in small animal practice.
Effective management necessitates a thorough understanding of the vomiting reflex's pathophysiology.
A rational approach integrates evidence-based decision-making.

Purpose of the Study:

To review the current evidence on the physiology of the vomiting reflex.
To outline the causes and consequences of emesis in dogs.
To assess diagnostic and therapeutic strategies for managing canine vomiting.

Main Methods:

Literature review assessing available scientific evidence.
Analysis of diagnostic testing modalities.
Evaluation of traditional and novel anti-emetic drug therapies.

Main Results:

The review details the vomiting reflex, common causes, and sequelae.
It discusses the efficacy of diagnostic tests and dietary interventions.
The utility of anti-emetic drugs, including in specific scenarios like post-cytotoxic therapy, is examined.

Conclusions:

Clinical practices for canine vomiting require further research to align with objective evidence.
Evidence-based guidelines for diagnosis and treatment are crucial.
Further research is needed to address gaps in current knowledge regarding canine emesis management.