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Updated: Jun 16, 2026
09:01
Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up
Published on: March 26, 2018
[Progress of research on leukemia stem/progenitor cell targeting therapy]
1Department of Hematology, Zhongda Hospital, Southeast University Clinical Medical College, Nanjing 210009, Jiangsu Province, China.
Zhongguo Shi Yan Xue Ye Xue Za Zhi
|February 9, 2010
Summary
Conventional chemotherapy often fails for hematological malignancies due to leukemia stem cells. Targeting these resilient cells offers a promising strategy for a complete cure.
Area of Science:
- Hematology
- Cancer Stem Cell Biology
- Oncology
Context:
- Conventional chemotherapy is the primary treatment for hematological malignancies.
- Relapse is common in patients treated with chemotherapy.
- Leukemia stem/progenitor cells are implicated in treatment failure and relapse.
Purpose:
- To review recent advancements in therapies targeting leukemia stem/progenitor cells.
- To highlight strategies for eradicating hematological malignancies by addressing the root cause of relapse.
Summary:
- Leukemia stem/progenitor cells possess self-renewal and differentiation capabilities, making them resistant to conventional chemotherapy.
- Traditional chemotherapeutic drugs primarily affect differentiated tumor cells, leaving leukemia stem/progenitor cells largely unaffected.
- Effective eradication of hematological malignancies requires targeting the unique properties of these stem/progenitor cells.
Impact:
- Developing targeted therapies against leukemia stem/progenitor cells is crucial for achieving complete tumor eradication and long-term remission.
- Strategies include targeting surface markers, inducing differentiation, disrupting signaling pathways, and modulating the stem cell niche.
- This research paves the way for novel therapeutic approaches to cure hematological malignancies.
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