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Updated: Jun 16, 2026
18:48
In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
Published on: August 12, 2017
[Research advance on transfusion-related immunomodulation].
1Department of Blood Transfution, Fudan University Huashan Hospital, Shanghai 200040, China.
Zhongguo Shi Yan Xue Ye Xue Za Zhi
|February 9, 2010
Summary
Allogeneic blood transfusions can cause immune side effects. This review explores transfusion-related immunomodulation (TRIM) mechanisms and mediators, including cloning deletion, anergy induction, and immune suppression.
Area of Science:
- Immunology
- Transfusion Medicine
Background:
- Allogeneic blood transfusions, while clinically beneficial, are associated with immune-related adverse effects.
- These effects include increased postoperative infection rates and higher relapse rates after malignant resections.
Purpose of the Study:
- To review the mechanisms of transfusion-related immunomodulation (TRIM).
- To identify the mediators involved in TRIM.
Main Methods:
- Review of clinical controlled trials.
- Analysis of laboratory research.
- Examination of animal models.
Main Results:
- TRIM is mediated by factors like CD200, interleukin, sHLA, and sFasL released from stored leukocytes.
- The primary mechanisms of TRIM are cloning deletion, anergy induction, and immune suppression.
Conclusions:
- Understanding TRIM mechanisms and mediators is crucial for mitigating transfusion-related immune side effects.
- Further research into TRIM can lead to safer transfusion practices.
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