[Impact of artificial esophagus slipped time upon the function formation of neoesophageal channel]

To observe the impact of artificial esophagus slipped time upon the function formation of neoesophageal channel, explore the scope of secure control time and assess the treatment methods of neoesophageal stenosis.

A total of 18 pigs in which artificial esophagus slipping at Month 1, 2, 3, 6 post-operation were observed with regards to complications, neoesophageal structures and functions and survival status of experimental animals.

Three pigs had a slip of artificial esophagus within a month post-operation and severe eating difficulties (Bown's Grade IV) because the neoesophagus had a severe narrowing (< 0.5 cm). All were dead shortly resulting from a failed treatment of esophageal dilation. Four pigs had a slip of artificial esophagus within 2 months post-operation. They all had dysphagia (Grade III-IV) as a result of moderate or severe neoesophageal stenosis (0.5 - 0.9 cm). Dysphagia was progressive. Repeated esophageal dilation was in vain. Three pigs were dead shortly and 1 pig achieved a long-term survival through a bare stent replacement therapy. Four pigs had a slip of artificial esophagus within 3 months post-operation. Dysphagia (Grade I-II) occurred as a result of mild or moderate neoesophageal stenosis (0.9 - 1.5 cm). Two pigs with moderate dysphagia achieved a long-term survival through a bare stent replacement therapy while another two were sacrificed. Seven had a slip of artificial esophagus at 3 months post-operation. The neoesophagus showed expansion and a relative narrowing (> 1.9 cm). Experimental animals had a mild difficulty in eating (Grade I), but it had an automatic relief. Experimental animals achieved a long-term survival and did not advance further.

Artificial esophagus (implant) stays in place for 2 - 3 months to form a functional esophageal channel. The longer an artificial esophagus is in place, a better channel of neoesophagus will form. Resetting a bare stent treatment of serious neoesophageal stenosis has significant therapeutic effects during this period. At 3 months post-operation, the slipping of artificial esophagus has little effects upon eating so that experimental animals may achieve a long-term survival.