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[An etiological study on acute respiratory infection among inpatient children in Suzhou]
1Department of Respiration, Children's Hospital Affiliated to Soochow University, Suzhou, China.
Insights
Respiratory syncytial virus (RSV) and human metapneumovirus (hMPV) are the primary viral causes of acute respiratory infections in Suzhou children. Identifying these pathogens aids accurate diagnosis and reduces antibiotic overuse.
Area of Science:
- Pediatric Infectious Diseases
- Virology
- Respiratory Medicine
Context:
- Acute respiratory infections (ARI) pose a significant health burden on children globally.
- Accurate identification of causative pathogens is crucial for effective treatment and management of pediatric ARI.
- Suzhou, China, experiences a notable incidence of pediatric respiratory illnesses.
Purpose:
- To identify the main viral pathogens responsible for acute respiratory infections in children in Suzhou.
- To provide evidence-based data for the clinical diagnosis and treatment of pediatric ARI.
- To analyze the epidemiological characteristics of identified viral pathogens in relation to age, season, and disease type.
Summary:
- A study investigated 2492 inpatient children with ARI in Suzhou from November 2005 to May 2007.
- Respiratory syncytial virus (RSV) and human metapneumovirus (hMPV) were identified as the predominant viral pathogens.
- Detection rates varied significantly by age, season, and specific respiratory illness, with RSV peaking in winter and hMPV detected year-round.
Impact:
- The findings highlight RSV and hMPV as key targets for intervention in pediatric respiratory infections in the region.
- Establishing etiological evidence aids clinicians in making faster, more accurate diagnoses.
- Improved diagnostic accuracy can lead to more judicious use of antibiotics, combating antimicrobial resistance.
Objective:
To investigate the pathogen of children with acute respiratory infection (ARI) in Suzhou and to provide some evidences for clinical diagnosis and treatment.
Methods:
The nasopharyngeal secretion samples from 2492 inpatient children with ARI, during the period of November 2005 to May 2007, were investigated for respiratory syncycial virus (RSV), influenza virus A and B, parainfluenza virus type 1, 2, 3 and adenovirus by both the indirect immunofluorescence assay and virus isolation. Human metapneumovirus (hMPV) were examined by reverse-transcription polymerase chain reaction (RT-PCR) at the same time.
Results:
Of 2492 samples tested, 961 (38.6%) were positive. The total positive rate of virus pathogens in children with ARI was found related to age, season and respiratory disease. The detection rates by age were: 50.0% (412/824), 43.4% (190/438), 30.5% (207/679)and 27.6% (152/551), chi(2) = 96.5002, P < 0.01; the detection rates by season were : 46.7% (366/784), 13.8% (66/478), 13.8% (59/428) and 58.6% (470/802), chi(2) = 392.3279, P < 0.01; the detection rates by disease were (acute upper respiratory infection, acute laryngitis, throat-trachea-bronchitis, bronchial pneumonia, pneumonia genuine, bronchiolitis, bronchial asthma): 21.4% (30/140), 73.7% (14/19), 32.0% (8/25), 36.9% (598/1620), 13.1% (8/61), 66.1% (216/327) and 29.0% (87/300), chi(2) = 162.1276, P < 0.01. There was no association between the total positive rate and sex. The detection rates by sex were: 39.0% (588/1508) for male and 37.9% (373/984) for female, chi(2) = 0.2962, P > 0.05. The peak of RSV appeared from December to March. There was the highest RSV detection rate 50.2% (164/327) with bronchiolitis. The hMPV can be detected all year around. The peak of hMPV appeared in winter and the detection rate was 13.2% (106/802).
Conclusion:
RSV and hMPV are the main respiratory viral pathogens in Suzhou. Detection of viral pathogens in children with respiratory infection could give fast, accurate diagnostic evidence, and help avoid antibiotics abuse.
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