Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

[Meta-analysis on relationship between hyperhomocysteinemia and multiple sclerosis].

Ying Zhu¹, He-nan Liu, Chao-dong Zhang

¹Department of Neurology, First Affiliated Hospital of China Medical University, Shengyang, China.

Zhonghua Yi Xue Za Zhi

|February 9, 2010

Summary

Elevated homocysteine levels, a condition known as hyperhomocysteinemia, are associated with multiple sclerosis (MS). This finding suggests a potential role for hyperhomocysteinemia in the pathological progression of MS.

Related Concept Videos

Multiple Sclerosis l: Introduction

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

[Material basis of Lianpu Drink in treatment of spleen-stomach dampness-heat syndrome based on chinmedomics].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica·2026

Same author

Emerging prodrug and nano-drug delivery strategies for the detection and elimination of senescent tumor cells.

Biomaterials·2025

Same author

Synthetic approaches and clinical application of representative small-molecule inhibitors of phosphodiesterase.

European journal of medicinal chemistry·2024

Same author

Synthetic routes and clinical application of new drugs approved by EMA during 2023.

European journal of medicinal chemistry·2024

Same author

Synthetic approaches and application of representative clinically approved fluorine-enriched anti-cancer medications.

European journal of medicinal chemistry·2024

Same author

Synthetic routes and clinical application of Small-Molecule HER2 inhibitors for cancer therapy.

Bioorganic chemistry·2024

Area of Science:

Neurology
Biochemistry
Medical Research

Context:

Multiple sclerosis (MS) is a chronic autoimmune disease affecting the central nervous system.
Hyperhomocysteinemia, characterized by elevated homocysteine levels, is a risk factor for various vascular and neurological conditions.
The potential link between hyperhomocysteinemia and MS pathogenesis requires further investigation.

Purpose:

To systematically review and meta-analyze existing literature to determine the relationship between hyperhomocysteinemia and multiple sclerosis.
To quantify the association between homocysteine levels and MS presence.
To assess the consistency and reliability of findings across multiple studies.

Summary:

A meta-analysis of nine case-control studies involving 1146 participants (676 MS patients, 470 controls) was conducted.

Related Experiment Videos

Results indicated significantly higher homocysteine levels in individuals with MS compared to healthy controls (SMD 1.25, 95% CI: 0.48 - 2.01).

Sensitivity analysis confirmed the robustness and coherence of the meta-analysis findings.

Impact:

Hyperhomocysteinemia is confirmed to be associated with multiple sclerosis.
The findings suggest that elevated homocysteine may play a role in the pathological course of MS.
This association could inform future research into MS etiology and potential therapeutic targets.