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Solventless visible light-curable coating: I. Critical formulation and processing parameters.

Sagarika Bose1, Robin H Bogner

  • 1Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, 69 North Eagleville Road, Storrs, Connecticut 06269, United States. bosesagarika@gmail.com

International Journal of Pharmaceutics
|February 9, 2010
PubMed
Summary

This study introduces a novel solventless photocurable film coating technology for pharmaceutical pellets. Key parameters like pore-former to monomer ratio are critical for efficient and uniform coating quality.

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Area of Science:

  • Pharmaceutical Sciences
  • Materials Science
  • Polymer Chemistry

Background:

  • Traditional film coating relies on solvents, posing environmental and safety concerns.
  • Solventless coating technologies offer a sustainable alternative for pharmaceutical applications.

Purpose of the Study:

  • To develop and evaluate a novel solventless photocurable film coating system for pharmaceutical pellets.
  • To identify critical formulation and processing parameters for optimizing coating quality and efficiency.

Main Methods:

  • A solventless coating system utilizing liquid photocurable monomer, pore-forming agents, photosensitizers, and photoinitiators was developed.
  • Pellets were coated in a mini-coating pan and cured using visible light.
  • Coating efficiency, yield, and physical attributes (color, diameter, roundness) were assessed.

Main Results:

  • Critical parameters influencing coating quality include the solid (pore-forming agent) to liquid (monomer) ratio (S/L ratio), pore-forming agent characteristics (particle size, type), initiator concentration, and light exposure.
  • An optimal S/L ratio of 1.8-3.0 was determined when using lactose as the pore-forming agent.
  • The S/L ratio was found to be sensitive to the particle size and type of the pore-forming agent.

Conclusions:

  • Solventless photocurable film coating is a viable technology for pharmaceutical pellets, overcoming limitations of solvent-based methods.
  • Careful control of formulation (S/L ratio, pore-former type/size) and processing (light exposure) is essential for achieving high-quality, uniform coatings.