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Bacterial enteritis as a risk factor for childhood intussusception: a retrospective cohort study
Cade M Nylund1, Lee A Denson, James M Noel
1Air Force Institute of Technology Wright Patterson Air Force Base, Cincinnati, OH, USA. cade.nylund@cchmc.org
Objective:
To assess the relationship between bacterial enteritis and intussusception.
Study Design:
The Patient Administration Systems and Biostatistics Activity database from January 2002 to December 2005 was examined for clinic visits or hospital admission to a Department of Defense medical facility for children age 0-5 years. The study included the International Statistical Classification of Diseases and Related Health Problems diagnosis-related group (DRG) codes for infections with Yersinia enterocolitica, Escherichia coli, Shigella species, Salmonella species, and Campylobacter. Identified patients were then assessed for the intussusception DRG code for 0-180 days postinfection. The total number of children enrolled in military treatment facilities in the same age group (denominator) was obtained.
Results:
Bacterial enteritis significantly increased the relative risk of intussusception. An increased risk was found following infection with Salmonella, E coli, Shigella, and Campylobacter. The relative risk for intussusception following any bacterial enteritis was 40.6 (95% confidence interval = 28.6-57.5; P < .0001).
Conclusions:
Bacterial enteritis is a significant risk factor for the subsequent development of intussusception in children.
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