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Updated: Jun 16, 2026
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A Unified Methodological Framework for Vestibular Schwannoma Research
Published on: June 20, 2017
Stereotactic radiation therapy for large vestibular schwannomas
Ellen S Mandl1, Otto W M Meijer, Ben J Slotman
1Neurosurgical Center Amsterdam, VU University Medical Center, 1007 MB Amsterdam, The Netherlands. es.mandl@vumc.nl
Summary
Stereotactic radiation therapy for large vestibular schwannomas (VS) showed an 82% tumor control rate but increased risks of facial and trigeminal nerve dysfunction compared to smaller tumors.
Area of Science:
- Neurosurgery
- Radiation Oncology
- Oncology
Background:
- Large vestibular schwannomas (VS) present unique treatment challenges.
- Stereotactic radiation therapy (SRT) and stereotactic radiosurgery (SRS) are treatment options for VS.
Purpose of the Study:
- To evaluate the morbidity and tumor-control rate in patients with large VS treated with SRT or SRS.
- To assess complications and long-term outcomes of radiation treatment for large VS.
Main Methods:
- Retrospective study of 25 consecutive patients with large VS (diameter ≥ 3.0 cm).
- Patients were treated with SRT or SRS between 1992 and 2007.
- Mean follow-up period of three years.
Main Results:
- Actuarial 5-year tumor control probability was 82%.
- Actuarial 5-year facial nerve preservation probability was 80%, with 5 of 17 patients experiencing new permanent dysfunction.
- Actuarial 5-year trigeminal nerve preservation probability was 85%, with 2 of 15 patients experiencing new permanent neuropathy.
Conclusions:
- Treatment of large VS with SRT or SRS is associated with increased morbidity rates.
- Morbidity rates are higher compared to published data on smaller VS and some previous studies on large VS.
