Nerve transfer for treatment of root avulsion of the brachial plexus: experimental studies in a rat model

In order to evaluate the effects of various nerve transfers, experimental rat models simulating root avulsions of the brachial plexus were created, using four different types of nerve transfers. Four groups of 160 rats were randomly divided, and phrenic nerves, double intercostal nerves, accessory nerves, and single intercostal nerves were transferred. Electrophysiologic and histologic examinations and functional evaluations were performed at different postoperative intervals. Phrenic nerve transfer was found to be superior to the other types most likely on the basis of superior neural regeneration. A single phrenectomy in the rat was found to have no apparent effect on pulmonary function.