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Levocabastine nasal spray significantly improves perennial allergic rhinitis: a single-blind placebo-controlled study
Kimihiro Okubo1, Eiji Uchida, Shoji Nogami
1Department of Otolaryngology, Nippon Medical School, 1-1-5, Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan. ent-kimi@nms.ac.jp
Objective:
The efficacy of levocabastine nasal spray for relieving the symptoms of perennial allergic rhinitis was compared with placebo in a single-blind study.
Methods:
Three hundred and thirty-five patients with moderate to severe perennial allergic rhinitis were randomized to three groups that were administered a high or low dose of levocabastine nasal spray or a placebo. Patients were not informed of their treatment. Efficacy was evaluated based on the changes of symptoms and rhinoscopy findings.
Results:
Significant improvement of symptoms was observed in both the high-dose and low-dose levocabastine groups compared with the placebo group. There were no significant differences of efficacy between the high-dose and low-dose levocabastine groups. There was also no significant difference in the occurrence of adverse effects among the three groups.
Conclusion:
Levocabastine nasal spray is a safe and effective treatment for perennial allergic rhinitis.
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