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The epidemiologic necropsy for abdominal aortic aneurysm.

M J McFarlane¹

¹Division of General Internal Medicine, Case Western Reserve University, Cleveland, Ohio.

|April 24, 1991

Summary

Epidemiologic necropsies reveal unsuspected abdominal aortic aneurysms. Necropsy findings align with screening surveys, validating this method for estimating disease prevalence in populations.

Area of Science:

Epidemiology
Pathology
Medical Research

Background:

The epidemiologic necropsy is a method to determine disease occurrence by examining necropsy records.
Estimates derived from necropsies should reflect disease prevalence in the living population.

Purpose of the Study:

To determine the occurrence rate of abdominal aortic aneurysms using necropsy records.
To compare necropsy detection rates of unsuspected abdominal aortic aneurysms with published screening survey data.

Main Methods:

Examination of necropsy records from the University of Kansas Medical Center (1950-1984).
Categorization of adult patients based on abdominal aortic aneurysm status: absent, unsuspected necropsy finding, or diagnosed/suspected during life.
Comparison of necropsy detection rates with five published screening surveys.

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Main Results:

The necropsy detection rate for abdominal aortic aneurysms was 1.9% in men (81/4155) and 0.9% in women (28/3142), a statistically significant difference.
When adjusted for demographic composition, necropsy results were statistically similar to screening survey findings.
UK screening surveys showed a 7.2% detection rate in white men, compared to a 5.8% necropsy detection rate.

Conclusions:

The epidemiologic necropsy is a valid research tool for estimating the prevalence of diseases like abdominal aortic aneurysms.
Necropsy data can accurately reflect disease occurrence in the general population when compared to screening methods.
This study supports the utility of necropsy records for epidemiological research.