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Updated: Jun 16, 2026

Flow Cytometric Analysis of Biomarkers for Detecting Human Sperm Functional Defects
Published on: April 21, 2022
Sperm DNA: organization, protection and vulnerability: from basic science to clinical applications--a position report
Christopher L R Barratt1, R John Aitken, Lars Björndahl
1Reproductive and Developmental Biology, Maternal and Child Health Science Laboratories, Centre for Oncology and Molecular Medicine, Ninewells Hospital, University of Dundee, Dundee DD1 9SY, UK. c.barratt@dundee.ac.uk
This ESHRE workshop focused on sperm DNA damage detection methods and their application in diagnosing and treating male infertility. It also assessed the reliability of these tests in identifying environmental and pharmaceutical impacts on male fertility.
Area of Science:
- Andrology
- Reproductive Biology
- Environmental Health
Background:
- Sperm DNA damage is linked to male infertility.
- Current diagnostic methods for sperm DNA damage require refinement.
- Understanding sperm chromatin vulnerability is crucial for fertility assessment.
Framework:
- The European Society of Human Reproduction and Embryology (ESHRE) convened a working group in May 2009.
- The workshop synthesized current knowledge on sperm chromatin structure and function.
- Recommendations for future basic and clinical research were developed.
Implementation:
- Focus on methods for detecting sperm DNA damage.
- Assessing the application of new knowledge on sperm chromatin organization, vulnerability, and repair.
- Evaluating the reliability of tests for environmental and pharmaceutical impacts on sperm DNA damage.
Implications:
- Improved diagnosis and treatment of male infertility associated with sperm DNA damage.
- Better identification of environmental and pharmaceutical agents contributing to male fertility issues.
- Guidance for future research directions in andrology and reproductive medicine.
Related Concept Videos
Sperm Structure and Semen Composition
Spermatogenesis
Fertilization

