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Related Experiment Video

Updated: Jun 16, 2026

SA-β-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs

SA-β-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs

Published on: June 28, 2019

Early growth and ageing.

J-H Chen¹, E C Cottrell, S E Ozanne

¹Institute of Metabolic Science, Metabolic Research Laboratories, University of Cambridge, Cambridge, UK.

Nestle Nutrition Workshop Series. Paediatric Programme

|February 9, 2010

Summary

This summary is machine-generated.

Early life conditions significantly impact adult health and longevity. Maternal protein restriction in rodents reveals links between early growth, insulin metabolism, oxidative stress, and lifespan regulation.

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Preparation and Culture of Myogenic Precursor Cells/Primary Myoblasts from Skeletal Muscle of Adult and Aged Humans

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Published on: February 16, 2017

Area of Science:

Developmental Biology
Gerontology
Metabolic Disease Research

Background:

Epidemiological studies link early life conditions to adult diseases like cardiovascular disease and type 2 diabetes.
Animal models are crucial for understanding the mechanisms connecting early development to adult health outcomes.
Maternal protein restriction in rodents has shown effects on longevity, highlighting the role of early growth patterns.

Purpose of the Study:

To explore the mechanisms by which in utero and early life conditions influence adult health and lifespan.
To investigate the role of insulin/IGF-1 signaling, oxidative damage, and SIRT1 in mediating these effects.
To examine the potential involvement of neuroendocrine systems and epigenetic modifications.

Main Methods:

Utilizing animal models, specifically rodent models of maternal protein restriction.
Analyzing changes in insulin metabolism, antioxidant defense systems, and oxidative damage markers.
Investigating the impact on telomere attrition and lifespan.

Main Results:

Maternal protein restriction alters insulin metabolism and antioxidant defense systems.
Early growth patterns influence oxidative damage levels, including telomere attrition.
These early environmental factors are implicated in the regulation of lifespan.

Conclusions:

Early life environment, particularly maternal nutrition, plays a critical role in regulating adult health and longevity.
Alterations in insulin signaling, oxidative stress, and epigenetic modifications are key mechanisms involved.
Further research is needed to fully elucidate these complex relationships and potential interventions.