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Related Experiment Videos

Elevated thrombin-antithrombin III complex concentrations in patients with gynaecological malignancy.

G Tatra1, A Reinthaller

  • 1II. Universitäts-Frauenklinik Wien.

Klinische Wochenschrift
|February 6, 1991
PubMed
Summary

Thrombin-antithrombin III-complex (TAT) levels can indicate coagulation activation in gynecologic cancers. Elevated TAT may signal disease presence or progression, aiding in monitoring treatment effectiveness.

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Area of Science:

  • Oncology
  • Hematology
  • Gynecology

Background:

  • Malignant tumors frequently cause hemostatic disorders.
  • Thrombin-antithrombin III (AT III) complex formation is a marker for intravascular coagulation activation.

Purpose of the Study:

  • To measure thrombin-antithrombin III-complex (TAT) levels in patients with gynecologic malignancies.
  • To assess the correlation between TAT levels and disease status, including presence, progression, and recurrence.

Main Methods:

  • Plasma TAT concentrations were measured in 153 patients with gynecologic malignancies.
  • The course of the disease and TAT levels were monitored in 21 cases.

Main Results:

  • 67% of patients (102/153) had elevated TAT levels before therapy.

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  • Decreased TAT levels were observed in patients with no evidence of disease after treatment.
  • Increased TAT levels correlated with tumor progression or recurrence.

    • Conclusions:

    • TAT plasma concentrations are a valuable indicator of thromboembolic risk in gynecologic malignancies.
    • TAT levels can provide insights into the disease course and response to therapy.