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Related Concept Videos

Thermosensation01:43

Thermosensation

Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
Constant Pressure Calorimetry03:02

Constant Pressure Calorimetry

Calorimetry is a technique used to measure the amount of heat involved in a chemical or physical process or to measure the heat transferred to or from a substance. The heat is exchanged with a calibrated and insulated device called the calorimeter. Calorimetry experiments are based on the assumption that there is no heat exchange between the insulated calorimeter and the external environment. The well-insulated calorimeters prevent the transfer of heat between the calorimeter and its external...
Temperature and Thermal Equilibrium01:11

Temperature and Thermal Equilibrium

Heat and temperature are essential concepts for everyone every day. The study of heat and temperature is part of an area of physics known as thermodynamics. It is not always easy to distinguish heat and temperature.
The concept of temperature has evolved from the common concepts of hot and cold. The scientific definition of temperature explains more than just our sense of hot and cold. Temperature is operationally defined as the quantity measured with a thermometer. Furthermore, temperature is...
The Molecular Nature of Internal Energy01:27

The Molecular Nature of Internal Energy

The internal energy of a molecule is determined by its degrees of freedom, including translational, rotational, and vibrational motions. In addition to these kinetic activities, the energy of molecules is also shaped by electronic energy, intermolecular forces, and the rest-mass energy of electrons and nuclei. These factors collectively influence the energy state of the molecules. The equipartition theorem of classical mechanics provides insight into this energy distribution. It posits that the...
Gas Thermometers and the Kelvin Scale01:22

Gas Thermometers and the Kelvin Scale

The definition of temperature in terms of molecular motion suggests that there should be a lowest possible temperature, where the average kinetic energy of molecules is zero (or the minimum allowed by quantum mechanics). Experiments confirm the existence of such a temperature, called absolute zero. An absolute temperature scale is one whose zero point is absolute zero. Such scales are convenient in science because several physical quantities, such as the volume of an ideal gas, are directly...
Equipments Used to Measure Body Temperature01:13

Equipments Used to Measure Body Temperature

Body temperature can be assessed using various devices and measured in Celsius or Fahrenheit.
Glass-bulb Thermometer:
Glass-bulb thermometers are hollow glass tubes with a bulb tip containing liquid such as ethanol or mercury. Historically, glass bulb mercury thermometers were the standard device to measure body temperature. Today, mercury thermometers are prohibited in many countries due to the hazardous effects of mercury and the risk of exposure if the glass bulb breaks. In general,...

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Thermal Measurement Techniques in Analytical Microfluidic Devices
08:29

Thermal Measurement Techniques in Analytical Microfluidic Devices

Published on: June 3, 2015

Molecular thermometry.

Kevin M McCabe1, Mark Hernandez

  • 1Department of Civil, Environmental, and Architectural Engineering [K.M.M., M.H.], University of Colorado at Boulder, Boulder, Colorado 80309, USA.

Pediatric Research
|February 9, 2010
PubMed
Summary
This summary is machine-generated.

Molecular thermometry uses advanced materials to measure temperature at the cellular level. This innovation promises earlier disease detection and more precise medical treatments.

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Last Updated: Jun 16, 2026

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Nanotechnology

Background:

  • Traditional thermometry relies on bulk material properties.
  • Early thermometers, like Galileo's and Santorio's, enabled clinical temperature measurement.
  • Modern advances enable real-time temperature reporting at the molecular level.

Observation:

  • Intracellular nanogels and heat-sensing biomolecules accurately report nanoscale temperature changes.
  • Emerging systems offer precise temperature measurement at tissue, cellular, and subcellular levels.
  • Nanomaterials are being developed for theranostic applications, including targeted drug delivery.

Findings:

  • Molecular thermometry provides unprecedented spatial resolution for temperature sensing.
  • These technologies allow for the detection of minute local temperature variations.
  • Nanomaterial systems exhibit theranostic potential for localized chemotherapy delivery.

Implications:

  • Enhanced early detection of tumors and localized infections.
  • Precise monitoring and management of hyperthermia therapies.
  • Potential for minimally invasive diagnostics and targeted therapeutics.