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Updated: Jun 16, 2026

Intermittent Binge-Intake Model in Mice
Published on: January 10, 2025
Bimodal control of stimulated food intake by the endocannabinoid system
Luigi Bellocchio1, Pauline Lafenêtre, Astrid Cannich
1INSERM U862, NeuroCentre Magendie, Endocannabinoids and Neuroadaptation, Bordeaux, France.
Abstract:
Activation of cannabinoid type-1 receptors (CB(1)) is universally recognized as a powerful endogenous orexigenic signal, but the detailed underlying neuronal mechanisms are not fully understood. Using combined genetic and pharmacological approaches in mice, we found that ventral striatal CB(1) receptors exerted a hypophagic action through inhibition of GABAergic transmission. Conversely, brain CB(1) receptors modulating excitatory transmission mediated the well-known orexigenic effects of cannabinoids.
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