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Updated: Jun 16, 2026

Measuring Granulocyte and Monocyte Phagocytosis and Oxidative Burst Activity in Human Blood
Published on: September 12, 2016
Agranulocytosis induced by multidrug therapy in leprosy treatment: a case report
Itathiana Ma C B da Silva1, Caroline A P de Oliveira, Wilma R C de A Guedes
1Infectious Diseases Service, Federal University of Paraíba, João pessoa, PB, Brazil. itathiana.silva@yahoo.com.br
Abstract:
Multidrug therapy (WHO/MDT) in multibacillary leprosy consists of treatment with rifampicin, dapsone and clofazimine. However, adverse effects can cause the patient to abandon treatment. We report on a patient who presented agranulocytosis and hemolytic anemia associated with this treatment regime. We also examined the importance of laboratory exams for diagnosis and follow-up of the patient, and for early detection of adverse effects,with a view to improving adhesion to treatment and contributing to the eradication of Hansen's disease as a public health issue.
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