Related Experiment Video
Updated: Jun 16, 2026
Development and Evaluation of a Rat Model of Full-Thickness Cartilage Defects
Published on: May 19, 2023
[Experimental model in rats for the development of pseudoarthrosis]
Manoel Luiz Ferreira1, Paulo Cesar Silva, Lara de Paula Miranda Pereira
1Departamento de Cirurgia, Faculdade de Medicina, UFRJ, Rio de Janeiro, RJ, BR.
Objective:
We sought to describe a new model of pseudoarthrosis in rats free of pathogenic species (Rattus norvegicus albinus - SPF).
Methods:
The animals were randomly distributed into two groups were used: Group 1 - Control (n =6); Group 2 - Experimental (n =6). In the Control group an access to the femur followed by the synthesis of the muscular and skin layers was done. The Experimental group was submitted to osteotomy of the femur and a pedicle flap of the fascia lata was interposed between the segments resulting from the surgically induced fracture. The procedure was carried on with both alignment and approximation of the fractured bone through the use of mononylon thread introduced into holes created in the proximal and distal.
Results:
Radiological and anatomopathological studies showed the absence of bone consolidation with persistence of fibro-osteoid tissue up to 120 days of follow-up.
Conclusion:
The experimental model is suitable for the development of a pseudoarthrosis in rats.
