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Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...

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Related Experiment Video

Updated: Jun 16, 2026

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge
09:53

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge

Published on: June 15, 2018

MicroRNAs in cardiac development.

Kimberly R Cordes1, Deepak Srivastava, Kathryn N Ivey

  • 1Gladstone Institute of Cardiovascular Disease and Department of Pediatrics, University of California, San Francisco, CA 94158, USA.

Pediatric Cardiology
|February 9, 2010
PubMed
Summary
This summary is machine-generated.

MicroRNAs (miRNAs) are key regulators in cardiovascular development, influencing cell processes like differentiation and vessel formation. Understanding these small RNAs offers potential for new therapeutic strategies in heart conditions.

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Last Updated: Jun 16, 2026

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Published on: February 24, 2017

Area of Science:

  • Cardiovascular Biology
  • Molecular Biology
  • Developmental Biology

Background:

  • Cardiovascular development relies on precise gene expression control.
  • Transcription factor mutations are linked to cardiovascular malformations.
  • MicroRNAs (miRNAs) represent a novel post-transcriptional regulatory mechanism in cardiogenesis.

Purpose of the Study:

  • To overview recent findings on miRNA regulation in cardiovascular development.
  • To highlight the roles of miRNAs in essential biologic processes.
  • To explore the potential for miRNA-based therapeutic strategies.

Main Methods:

  • Literature review of recent findings on miRNA regulation in cardiovascular development.
  • Analysis of miRNA functions in cardiomyocyte differentiation, cell cycle, conduction, and vessel formation.
  • Identification of miRNAs expressed in specific cardiac and vascular cell types.

Main Results:

  • miRNAs are central regulators of cardiogenic processes.
  • Specific miRNAs play critical roles in cardiomyocyte differentiation, cell cycle, conduction, and vessel formation.
  • miRNAs are involved in cell proliferation, differentiation, apoptosis, and stress response.

Conclusions:

  • miRNAs are crucial for cardiovascular development.
  • Further research into miRNA function can lead to novel therapeutic strategies for cardiovascular diseases.
  • Understanding miRNA roles in cardiac and vascular cells is essential.