Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Genetics, haloperidol and pimozide: a comparative study in two mouse strains.

F S Messiha1

  • 1Department of Pharmacology, University of North Dakota School of Medicine, Grand Forks 58203.

Neurotoxicology
|January 1, 1991
PubMed
Summary

Genetic factors influence how haloperidol and pimozide affect brain chemistry in Tourette's syndrome (TS) management. Drug responses vary between mouse strains, impacting potential side effects and treatment efficacy in TS patients.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Developmental toxicity of cesium in the mouse.

General pharmacology·1994
Same author

Pharmacological aspects of gonadal alcohol and aldehyde-dehydrogenase.

General pharmacology·1993
Same author

beta-Casomorphin-immunoreactivity in the brain stem of the human infant.

Research communications in chemical pathology and pharmacology·1993
Same author

Fluoxetine: adverse effects and drug-drug interactions.

Journal of toxicology. Clinical toxicology·1993
Same author

Classifying cytostatics on the basis of their angiocidal and angiostatic effects.

Journal of medicine·1993
Same author

Fluoxetine: a spectrum of clinical applications and postulates of underlying mechanisms.

Neuroscience and biobehavioral reviews·1993

Area of Science:

  • Neuropharmacology
  • Genetics
  • Tourette's Syndrome Research

Background:

  • Haloperidol and pimozide are primary medications for Tourette's syndrome (TS).
  • TS is linked to dopaminergic overactivity and potential genetic factors.
  • Understanding drug mechanisms and genetic influences is crucial for TS treatment.

Purpose of the Study:

  • To investigate the strain-dependent effects of haloperidol and pimozide on brain biogenic amines and metabolites.
  • To explore the relationship between genetic background and neuroleptic drug action in a TS model.
  • To correlate observed neurochemical changes with known side effect profiles.

Main Methods:

  • Comparative analysis of haloperidol and pimozide effects in two genetically distinct mouse strains (BALB/c and C57BL/6).

Related Experiment Videos

  • Measurement of regional brain levels of biogenic amines and their acidic metabolites.
  • Assessment of dopamine and serotonin turnover rates.

    • Main Results:

    • Haloperidol showed higher striatal dopamine turnover than pimozide in BALB/c mice, but not C57BL/6 mice.
    • Pimozide decreased serotonin turnover more than haloperidol in C57BL/6 mice, but not BALB/c mice.
    • Significant strain-dependent variations in drug effects on neurotransmitter systems were observed.

    Conclusions:

    • Genetic factors play a role in the cerebral potency and efficacy of neuroleptics used for Tourette's syndrome.
    • Observed strain-specific neurochemical changes may explain differential side effect profiles (e.g., extrapyramidal symptoms, sedation).
    • These findings highlight the importance of considering genetic variability in TS pharmacotherapy.