LigaSure compared with ligatures and endoclips in experimental appendectomy: how safe is it?

Area of Science:

• Surgical innovation
• Experimental surgery
• Gastrointestinal surgery

Background:

• Appendectomy stump closure is critical for preventing complications.
• Various methods exist, including sutures, clips, and energy devices.
• Optimizing stump closure impacts patient outcomes and surgical efficiency.

Purpose of the Study:

• To compare the efficacy of LigaSure Precise device versus traditional methods for appendiceal stump closure.
• To evaluate differences in stump strength, healing, inflammation, and operation time.
• To assess the impact of different closure techniques on postoperative outcomes in an experimental model.

Main Methods:

• Forty-eight rats underwent appendectomy with stump closure using LigaSure, polyglactin 910 ligatures, or endoclips.
• Cecum bursting pressures were measured immediately and on day 7 post-operation.
• Histological evaluation and hydroxyproline levels (collagen content) were assessed on day 7.

Main Results:

• Bursting pressures were comparable across all groups immediately and at 7 days.
• LigaSure group showed significantly higher hydroxyproline levels (indicating better healing) and shorter operation times.
• The LigaSure group exhibited the least inflammation on histological examination.

Conclusions:

• LigaSure Precise device offers advantages in appendiceal stump closure, promoting better healing and reduced inflammation.
• The device achieves comparable stump strength to traditional methods.
• Shorter operation times and improved healing make LigaSure a promising alternative in experimental appendectomy.