Related Experiment Video

Updated: Jun 16, 2026

Continuous Video Electroencephalogram during Hypoxia-Ischemia in Neonatal Mice
09:29

Continuous Video Electroencephalogram during Hypoxia-Ischemia in Neonatal Mice

Published on: June 11, 2020

Status epilepticus and capillary leak syndrome in a neonate related to perinatal hypoxic-ischemic encephalopathy

Belma Saygili Karagol1, Omer Erdeve, Saadet Arsan

  • 1Division of Neonatology, Department of Pediatrics, Ankara University School of Medicine, Cayyolu/Ankara, Turkey. belmakaragol@yahoo.com

Indian Journal of Pediatrics
|February 9, 2010
PubMed

Insights

Perinatal hypoxic-ischemic encephalopathy can lead to neurological deficits like cerebral palsy. This case highlights co-occurring capillary leak syndrome and status epilepticus in a newborn with this condition.

Area of Science:

  • Neurology
  • Pediatrics
  • Neonatology

Background:

  • Hypoxic-ischemic encephalopathy (HIE) is a major cause of childhood neurological deficits, including cerebral palsy.
  • Perinatal HIE results from oxygen deprivation during birth, impacting the brain.
  • Cerebral palsy encompasses a group of movement disorders originating in the developing brain.

Observation:

  • This report details a specific case of neonatal hypoxic-ischemic encephalopathy.
  • The patient presented with co-morbid capillary leak syndrome.
  • The newborn also experienced seizures, indicative of status epilepticus.

Findings:

  • The case illustrates a rare association between capillary leak syndrome and status epilepticus in the context of perinatal HIE.
  • This combination of conditions presents a complex clinical challenge in neonates.
  • The findings underscore the multifaceted nature of HIE complications.

Implications:

  • Understanding these co-morbidities is crucial for effective management of HIE.
  • Early recognition and intervention for capillary leak syndrome and status epilepticus may improve outcomes.
  • This case contributes to the literature on severe neonatal neurological injury and its associated systemic complications.

More Related Videos

A Piglet Model of Neonatal Hypoxic-Ischemic Encephalopathy10:30

A Piglet Model of Neonatal Hypoxic-Ischemic Encephalopathy

Published on: May 16, 2015

Related Concept Videos

Hepatic Encephalopathy01:29

Hepatic Encephalopathy

DefinitionHepatic encephalopathy is a reversible neurologic syndrome that results from advanced liver dysfunction or portosystemic shunting. It leads to disturbances in cognition, behavior, and motor function due to the brain’s exposure to gut-derived toxins that the liver fails to detoxify.EtiologyThis condition develops either in the setting of acute fulminant hepatitis or progressively during chronic liver disease, such as cirrhosis and portal hypertension. Portosystemic shunting—including...
Cerebral Edema ll: Pathophysiology01:22

Cerebral Edema ll: Pathophysiology

Vasogenic edema is a major form of cerebral edema characterized by abnormal accumulation of fluid in the brain’s extracellular space due to disruption of the blood–brain barrier (BBB). The BBB is a specialized structure composed of endothelial cells connected by tight junctions, supported by astrocytic endfeet and a basement membrane. Under normal conditions, it tightly regulates the movement of ions, proteins, and solutes between the bloodstream and brain parenchyma. When this barrier loses...
Seizures l: Introduction01:20

Seizures l: Introduction

Understanding seizures and epilepsy relies on key definitions that help in recognizing, classifying, and managing these disorders. These definitions provide a framework for recognizing, classifying, and managing seizure disorders.DefinitionsA seizure is a sudden, abnormal burst of electrical activity in the brain that can cause changes in awareness, movement, sensation, or behavior, depending on the area involved. Epilepsy is a chronic condition characterized by recurrent, unprovoked seizures,...
Cytotoxic Edema: Pathophysiology01:21

Cytotoxic Edema: Pathophysiology

Cytotoxic edema is a form of cerebral edema characterized by intracellular swelling of neurons, astrocytes, and other glial cells. It develops when the mechanisms responsible for maintaining ionic gradients across the cell membrane become impaired. Under normal physiological conditions, the sodium–potassium ATPase actively transports sodium ions out of the cell and potassium ions into the cell, preserving osmotic balance and enabling electrical signaling. This pump requires a continuous supply...
Encephalitis l: Introduction01:19

Encephalitis l: Introduction

Encephalitis is inflammation of the brain parenchyma, most often due to infections or autoimmune processes. It presents with neuropsychiatric features such as fever, altered mental status, behavioral changes, cognitive dysfunction, seizures, focal deficits, and sometimes autonomic instability. In some cases, the meninges are also involved, resulting in meningoencephalitis.Infectious CausesInfectious encephalitis is most commonly viral but can also result from bacterial, fungal, or parasitic...
Epilepsy and Seizures: Overview01:24

Epilepsy and Seizures: Overview

Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...