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Updated: Jun 16, 2026

Yeast As a Chassis for Developing Functional Assays to Study Human P53
Published on: August 4, 2019
[P53 abnormality and clinical prognosis of leukemia patients with complex chromosomal abnormalities]
Zhaoling Zou1, Xiangshan Cao, Zhilin Wang
1Department of Hematology, the Third Affiliated Hospital of Soochou University, the First People's Hospital of Changzhou, Changzhou, Jiangsu, 213003 P.R. China.
Objective:
To investigate the p53 deletion in leukemia patients with complex chromosomal abnormalities (CCA) and the clinical significance.
Methods:
The p53 deletion status of 38 leukemia cases with CCA and 24 cases without CCA were analyzed by interphase fluorescence in situ hybridization (I-FISH).
Results:
The frequency of p53 deletion in the 38 patients with CCA (44.74%) was significantly higher than that in the 24 cases without CCA (4.16%) (P<0.01). The rate of complete remission in 13 cases of acute leukemia with CCA was 15.4%, with median survival time (MST) of 105 days.
Conclusion:
I-FISH is a rapid, accurate and sensitive technique for detection of p53 deletion, patients with CCA have a higher p53 deletion and a lower complete remission rate and MST.
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