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Updated: Jun 16, 2026

Murine Model of Wound Healing
05:39

Murine Model of Wound Healing

Published on: May 28, 2013

The challenge of using randomized trials in wound healing

F Gottrup1, J Apelqvist

  • 1Copenhagen Wound Healing Center, Department of Dermatology, D42, Bispebjerg University Hospital, Copenhagen NV, Denmark. fgottrup@post4.tele.dk

The British Journal of Surgery
|February 9, 2010
PubMed
Summary

No abstract available in PubMed .

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The randomization process involves assigning study participants randomly to experimental or control groups based on their probability of being equally assigned. Randomization is meant to eliminate selection bias and balance known and unknown confounding factors so that the control group is similar to the treatment group as much as possible. A computer program and a random number generator can be used to assign participants to groups in a way that minimizes bias.
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Blinding is a commonly used method of not telling participants which treatment a subject is receiving. Blinding is a critical part of a randomized control trial or RCT. It reduces the bias that affects the results. In an RCT, blinding is used in the form of a placebo. A placebo effect occurs when untreated subjects falsely believe they have received the treatment and report improved symptoms. A placebo or a dummy treatment is administered to subjects to negate the bias caused by such an effect.