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Published on: February 19, 2019
[Bile biochemical composition changes in patients with chronic viral hepatitis]
Terapevticheskii Arkhiv
|February 10, 2010
Summary
Patients with viral hepatitis show decreased cholic acid (CA) levels and impaired bile secretion, indicating biliary insufficiency. This study highlights the need for biochemical bile analysis to diagnose liver exocrine dysfunction in these patients.
Area of Science:
- Hepatology
- Biochemistry
- Gastroenterology
Background:
- Viral hepatitis significantly impacts liver function.
- Bile composition and secretion are crucial for duodenal digestion.
- Understanding exocrine liver function is vital for managing hepatitis.
Purpose of the Study:
- To investigate the biochemical profile of cystic and hepatic bile in viral hepatitis patients.
- To assess alterations in bile components and their ratios.
- To determine the presence and extent of biliary insufficiency.
Main Methods:
- Biochemical analysis of bile from 457 viral hepatitis patients.
- Measurement of cholic acid (CA), cholesterol, bilirubin, phospholipids, calcium, and C-reactive protein.
- Calculation of cholate-cholesterol and phospholipid-cholesterol ratios.
Main Results:
- Significantly decreased CA levels and cholate-cholesterol ratios observed in all viral hepatitis patients.
- Evidence of impaired duodenal digestion and reduced CA secretion.
- A majority of patients exhibited signs of biliary insufficiency.
Conclusions:
- Viral hepatitis leads to reduced bile secretion and biliary insufficiency.
- Biochemical bile analysis is essential for diagnosing exocrine liver dysfunction.
- Stepwise duodenal intubation with biochemical analysis aids in complex liver exocrine function diagnosis.
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