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Elevated blood lactate is associated with increased motor cortex excitability.

Marinella Coco¹, Giovanna Alagona, Giuseppe Rapisarda

¹Department of Physiological Sciences, University of Catania, Catania, Italy.

Somatosensory & Motor Research

|February 10, 2010

Summary

High blood lactate levels enhance motor cortex excitability. This suggests lactate may protect the motor cortex from fatigue during intense exercise.

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Area of Science:

Neuroscience
Exercise Physiology

Background:

Limited understanding of blood lactate's impact on cerebral cortex excitability.
Motor cortex plays a crucial role in voluntary movement control.

Purpose of the Study:

To investigate the effects of elevated blood lactate on motor cortex excitability.
To determine if induced hyperlactatemia influences cortical excitability.

Main Methods:

17 male athletes underwent maximal cycling tests or intravenous lactate infusion.
Venous blood lactate levels were measured before, during, and after interventions.
Motor cortex excitability was assessed using transcranial magnetic stimulation.

Main Results:

Increased blood lactate levels correlated with a reduced motor threshold.
This indicates enhanced motor cortex excitability under high lactate conditions.
Findings were consistent across both exercise and infusion protocols.

Conclusions:

Elevated blood lactate enhances motor cortex excitability.
Lactate may play a neuroprotective role against fatigue in the motor cortex.
Further research is warranted to elucidate the mechanisms involved.