Related Experiment Videos
Lipoproteins in children treated with continuous peritoneal dialysis
U Querfeld1, R C LeBoeuf, I B Salusky
1Department of Pediatrics, UCLA School of Medicine 90024.
Pediatric Research
|February 1, 1991
Summary
Pediatric patients on continuous peritoneal dialysis exhibit unhealthy lipid profiles, including elevated triglycerides and cholesterol, despite normal high-density lipoprotein cholesterol. Significant protein losses occur during dialysis.
Area of Science:
- Pediatric Nephrology
- Clinical Biochemistry
- Lipid Metabolism
Background:
- Continuous peritoneal dialysis (CPD) is a treatment for pediatric kidney failure.
- Patients undergoing CPD may experience altered lipid metabolism and protein loss.
- Understanding these changes is crucial for managing long-term health in these children.
Purpose of the Study:
- To investigate lipid and apolipoprotein profiles in pediatric patients undergoing CPD.
- To compare these profiles with healthy controls.
- To assess the relationship between lipid profiles, nutritional status, and protein losses in dialysate.
Main Methods:
- Plasma lipids (total cholesterol, triglycerides) and lipoproteins (VLDL, LDL, HDL) were measured.
- Apolipoproteins A-I (apo A-I) and B (apo B) were quantified.
- Dialysate concentrations of apo A-I and apo B were analyzed in a subset of patients.
Main Results:
- CPD patients showed significantly elevated total plasma triglycerides, VLDL triglycerides, total cholesterol, VLDL cholesterol, and LDL cholesterol compared to controls.
- HDL cholesterol and apo A-I levels were normal in patients.
- Plasma apo B levels were elevated, and significant amounts of apo A-I and apo B were lost in the dialysate.
Conclusions:
- Pediatric patients on CPD have atherogenic lipoprotein profiles and altered cholesterol and apolipoprotein ratios.
- Despite substantial apo A-I losses in dialysate, plasma apo A-I levels remained normal.
- Lipoprotein profiles were not correlated with nutritional status in this cohort.