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Distribution of endotracheally instilled surfactant protein SP-C in lung-lavaged rabbits
S B Oetomo1, L de Ley, T Curstedt
1Department of Pediatrics, State University Groningen, The Netherlands.
Pediatric Research
|February 1, 1991
Abstract:
In lung-lavaged surfactant-deficient rabbits (n = 6) requiring artificial ventilation, porcine surfactant was instilled endotracheally. This resulted in improvement of lung function so that the animals could be weaned off artificial ventilation. The animals were killed 4 1/2 h after surfactant administration and the porcine surfactant protein was localized in the lung with a MAb. We found surfactant protein in all lobes of the lung but the distribution was not homogeneous. Surfactant protein C was found in less than 15% of the alveolar spaces and in less than 1% of the bronchi.