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Updated: Jun 16, 2026

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
Published on: November 10, 2017
Treating dyslipidemia in the high-risk patient
1Lipid Metabolism and Atherosclerosis Clinic, Baylor College of Medicine, Houston, TX, USA. jones@bcm.tmc.edu
Abstract:
Clinical trials demonstrate that cardiovascular event rates diminish as low-density lipoprotein (LDL)-cholesterol and apolipoprotein B-containing particles are lowered with statin treatment. The relationship between LDL-cholesterol and cardiovascular events seems to be linear, with no lowest threshold. While LDL-cholesterol remains the primary target for coronary heart disease prevention, non-HDL-cholesterol is an important secondary target in patients with mixed dyslipidemia.
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