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Related Concept Videos

Depressive Disorders: MDD and Dysthymia01:27

Depressive Disorders: MDD and Dysthymia

Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
Depression: Overview01:18

Depression: Overview

Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
Long-term Depression01:05

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Long-term Depression01:03

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over time, all...
Depressive Disorders: Etiology01:27

Depressive Disorders: Etiology

Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Diagnostic and Statistical Manual of Mental Disorders (DSM)01:27

Diagnostic and Statistical Manual of Mental Disorders (DSM)

The Diagnostic and Statistical Manual of Mental Disorders (DSM) serves as the primary classification system for mental health disorders, providing standardized diagnostic criteria for clinicians and researchers. First published by the American Psychiatric Association (APA) in 1952, the DSM has undergone several revisions to reflect evolving psychiatric understanding. The fifth edition, DSM-5, released in 2013, introduced key updates that expanded diagnostic categories and modified diagnostic...

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Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder
04:33

Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder

Published on: April 26, 2024

[Severe depression : which concept ? which criteria].

A Pélissolo1

  • 1Service de psychiatrie adulte et CNRS USR 3246, Hôpital Pitié-Salpêtrière, 47 bd de l'Hôpital, 75013 Paris. Antoine.pelissolo@psl.aphp.fr

L'Encephale
|February 10, 2010
PubMed
Summary

Defining severe depression is crucial for public health. This review explores qualitative and quantitative methods, highlighting the need for consensus on severity markers and assessment scales in clinical studies.

Area of Science:

  • Psychiatry and Mental Health
  • Clinical Psychology

Context:

  • Depression is a prevalent public health concern with varied severity levels.
  • Current treatment strategies are individualized but lack consensus on defining severe depression.

Purpose:

  • To review and discuss qualitative and quantitative options for defining depression severity.
  • To examine international classification criteria and clinical severity markers.

Summary:

  • International classifications use diagnostic criteria counts for mild, moderate, and severe depression.
  • Qualitative factors include psychotic symptoms, melancholia, and endogenous signs.
  • Quantitative scales and clinical judgment are combined in study inclusion criteria for severe depression.

Impact:

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  • Aims to inform the development of standardized criteria for severe depression.
  • Facilitates more consistent patient stratification in clinical research.
  • Enhances understanding of depression severity for improved treatment tailoring.