Related Experiment Video
Updated: Jun 16, 2026

10:50
Transcript and Metabolite Profiling for the Evaluation of Tobacco Tree and Poplar as Feedstock for the Bio-based Industry
Published on: May 16, 2014
Fragrance material review on isophytol
D McGinty1, C S Letizia, A M Api
1Research Institute for Fragrance Materials, Inc., Woodcliff Lake, NJ 07677, USA. dmcginty@RIFM.org
Summary
This review examines the toxicologic and dermatologic safety of isophytol, a common fragrance ingredient. It provides a comprehensive safety assessment for its use in consumer products.
Area of Science:
- Toxicology
- Dermatology
- Fragrance Chemistry
Background:
- Isophytol is a widely used fragrance ingredient in various consumer products.
- Understanding its toxicologic and dermatologic profile is crucial for consumer safety.
- Previous safety data may be limited or require consolidation.
Purpose of the Study:
- To conduct a comprehensive toxicologic and dermatologic review of isophytol.
- To evaluate the safety of isophytol as a fragrance ingredient.
- To identify potential risks associated with isophytol exposure.
Main Methods:
- Literature review of existing toxicologic studies.
- Dermatologic assessment of potential skin reactions.
- Analysis of safety data relevant to fragrance applications.
Main Results:
- Isophytol demonstrates a generally favorable toxicologic profile.
- Dermatologic assessments indicate low potential for skin irritation or sensitization.
- Existing data supports the safe use of isophytol within established concentration limits.
Conclusions:
- Isophytol is considered safe for use as a fragrance ingredient based on current toxicologic and dermatologic data.
- Further research may focus on long-term exposure effects or specific population sensitivities.
- Regulatory bodies can utilize this review for informed safety assessments.
Related Concept Videos
Physical Properties of Alcohols and Phenols
Alcohols are organic compounds in which a hydroxy group is attached to a saturated carbon. Phenols are a class of alcohols containing a hydroxy group attached to an aromatic ring. The physical properties of the alcohols and phenols are influenced by hydrogen bonding due to the oxygen–hydrogen dipole in the hydroxy functional group and dispersion forces between alkyl or aryl regions of alcohol and phenol molecules.
Alcohols possess a higher boiling point than aliphatic hydrocarbons of similar...
Alcohols possess a higher boiling point than aliphatic hydrocarbons of similar...
Structure and Nomenclature of Alcohols and Phenols
Overview
Alcohols are one of the most important functional groups in organic chemistry. The name of alcohol comes from the hydrocarbon from which it is derived. Alcohols are organic molecules containing the functional hydroxyl or –OH group directly bonded to carbon. Phenols have an OH group directly attached to a benzene ring. While alcohols are colorless, phenol is a white crystalline compound with a characteristic "hospital smell" odor.
As with other organic compounds, alcohols and phenols...
Alcohols are one of the most important functional groups in organic chemistry. The name of alcohol comes from the hydrocarbon from which it is derived. Alcohols are organic molecules containing the functional hydroxyl or –OH group directly bonded to carbon. Phenols have an OH group directly attached to a benzene ring. While alcohols are colorless, phenol is a white crystalline compound with a characteristic "hospital smell" odor.
As with other organic compounds, alcohols and phenols...

