Related Experiment Video

Updated: Jun 16, 2026

Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure
05:16

Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure

Published on: June 10, 2025

Prognosis of stage A or B heart failure patients with elevated B-type natriuretic peptide levels

Lori B Daniels1, Paul Clopton, Kevin Jiang

  • 1Division of Cardiology, Department of Medicine, University of California at San Diego, San Diego, CA, USA. lbdaniels@ucsd.edu

Journal of Cardiac Failure
|February 10, 2010
PubMed

Insights

B-type natriuretic peptide (BNP) can identify asymptomatic individuals at high risk for heart failure (HF). Even without HF history, elevated BNP levels (>or=100pg/mL) indicate a prognosis similar or worse than symptomatic HF patients with lower BNP.

Area of Science:

  • Cardiology
  • Biomarkers
  • Prognostics

Background:

  • Heart failure (HF) patients face poor prognoses, necessitating early risk identification.
  • Investigating B-type natriuretic peptide (BNP) prognostic value in early-stage HF (ACC/AHA Stages A and B).
  • Comparing prognosis of early-stage HF patients with advanced-stage (C/D) HF patients.

Purpose of the Study:

  • To evaluate the prognostic significance of BNP in patients at risk for HF (Stages A and B).
  • To compare the outcomes of Stage A/B patients with elevated BNP to Stage C/D patients with lower BNP levels.

Main Methods:

  • Eighty-two outpatients were stratified by ACC/AHA HF stage and BNP levels (cutpoint 100 pg/mL).
  • Primary outcome: 1-year death or cardiac hospitalization.
  • Analysis of BNP levels in relation to cardiovascular risk factors and HF stage.

Main Results:

  • BNP levels correlated positively with cardiovascular risk factors and HF stage.
  • Stage A/B patients with high BNP (>or=100 pg/mL) showed similar or worse prognosis than Stage C/D patients with low BNP (<100 pg/mL).
  • Stage A/B patients with high BNP had a significantly worse prognosis (adjusted HR 1.91).

Conclusions:

  • Elevated BNP levels (>=100 pg/mL) in individuals without HF history indicate risk equal to or greater than HF patients with lower BNP.
  • BNP is a valuable tool for identifying asymptomatic individuals at high risk for future cardiovascular events.
Abstract

More Related Videos

Clinical Application of Phase Angle and BIVA Z-Score Analyses in Patients Admitted to an Emergency Department with Acute Heart Failure04:05

Clinical Application of Phase Angle and BIVA Z-Score Analyses in Patients Admitted to an Emergency Department with Acute Heart Failure

Published on: June 30, 2023

Related Concept Videos

Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
Heart Failure IV: Classification and Diagnostic Evaluation01:30

Heart Failure IV: Classification and Diagnostic Evaluation

Heart failure can be classified in various ways, with the most common classifications based on physical activity limitations, disease progression, severity, and treatment strategies.The Functional Classification of Heart Failure divides patients into four categories based on physical activity limitation due to symptom burden.Class I: Patients in this class have cardiac disease but no physical activity limitations. Ordinary activities like walking, climbing stairs, or routine tasks do not cause...
Heart Failure VII: Nursing Interventions01:30

Heart Failure VII: Nursing Interventions

The first step in nursing management of a patient with heart failure involves thoroughly assessing the patient's medical history.Subjective Data: Obtain the patient's medical history of coronary artery disease, hypertension, myocardial infarction, and symptoms like dyspnea, orthopnea, and paroxysmal nocturnal dyspnea.Objective Data: Conduct a physical examination to identify findings such as jugular vein distention, pulmonary crackles, tachycardia, murmurs, peripheral edema, and vital signs,...
Heart Failure Drugs: &#946;-Blockers01:22

Heart Failure Drugs: β-Blockers

β-adrenergic antagonists, commonly known as β-blockers, block the effects of sympathetic neurotransmitters such as noradrenaline (NA) and adrenaline (ADR). They have several beneficial effects in heart failure treatment. They reduce heart rate, the force of contraction, and cardiac muscle relaxation. They also slow the atrial-ventricular conduction rate and raise the threshold for arrhythmias. The concentration of β-blockers determines their effects on bronchodilation, vasodilation, and...
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...