Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bonding in Metals02:32

Bonding in Metals

Metallic bonds are formed between two metal atoms. A simplified model to describe metallic bonding has been developed by Paul Drüde called the “Electron Sea Model”.
Theory of Metallic Conduction01:17

Theory of Metallic Conduction

The conduction of free electrons inside a conductor is best described by quantum mechanics. However, a classical model makes predictions close to the results of quantum mechanics. It is called the theory of metallic conduction.
In this theory, Newton's second law of motion is used to determine the acceleration of an electron in the presence of an applied electric field. Then, its velocity is expressed via this acceleration.
An electron moves through the crystal, containing positive ions,...
Metallic Solids02:37

Metallic Solids

Metallic solids such as crystals of copper, aluminum, and iron are formed by metal atoms. The structure of metallic crystals is often described as a uniform distribution of atomic nuclei within a “sea” of delocalized electrons. The atoms within such a metallic solid are held together by a unique force known as metallic bonding that gives rise to many useful and varied bulk properties.
All metallic solids exhibit high thermal and electrical conductivity, metallic luster, and malleability. Many...
Metal-Ligand Bonds02:51

Metal-Ligand Bonds

The hemoglobin in the blood, the chlorophyll in green plants, vitamin B-12, and the catalyst used in the manufacture of polyethylene all contain coordination compounds. Ions of the metals, especially the transition metals, are likely to form complexes.
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
Properties of Transition Metals02:58

Properties of Transition Metals

Transition metals are defined as those elements that have partially filled d orbitals. As shown in Figure 1, the d-block elements in groups 3–12 are transition elements. The f-block elements, also called inner transition metals (the lanthanides and actinides), also meet this criterion because the d orbital is partially occupied before the f orbitals.
Metal-Semiconductor Junctions01:24

Metal-Semiconductor Junctions

The contact of metal and semiconductor can lead to the formation of a junction with either Schottky or Ohmic behavior.
Schottky Barriers
Schottky barriers arise when a metal with a work function (Φm) contacts a semiconductor with a different work function (Φs). Initially, electrons transfer until the Fermi levels of the metal and semiconductor align at equilibrium. For instance, if Φm > Φs, the semiconductor Fermi level is higher than the metal's before contact. The semiconductor's...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Metal-mediated peptide processing. How copper and iron catalyze diverse peptide modifications such as amidation and crosslinking.

RSC chemical biology·2025
Same author

The binuclear copper state of peptidylglycine monooxygenase visualized through a selenium-substituted peptidyl-homocysteine complex.

Dalton transactions (Cambridge, England : 2003)·2025
Same author

Mechanisms of Copper Selectivity and Release by the Metallochaperone CusF: Insights from CO-Binding, Rapid-Freeze-Quench EXAFS, and Unnatural Amino Acid Substitution.

Inorganic chemistry·2024
Same author

Pathogenic R<sub>163</sub>W Variant of the Copper Chaperone for Sod1 (Ccs) Functions as an Anti-chaperone.

Biochemistry·2024
Same author

Ripping and stitching with copper.

Nature chemical biology·2024
Same author

Capturing the Binuclear Copper State of Peptidylglycine Monooxygenase Using a Peptidyl-Homocysteine Lure.

Journal of the American Chemical Society·2024
Same journal

The Hedgehog Pathway Effector Smoothened Exhibits Signaling Competency in the Absence of Ciliary Accumulation.

Chemistry & biology·2017
Same journal

DIVERSE System: De Novo Creation of Peptide Tags for Non-enzymatic Covalent Labeling by In Vitro Evolution for Protein Imaging Inside Living Cells.

Chemistry & biology·2015
Same journal

Differential Regulation of Specific Sphingolipids in Colon Cancer Cells during Staurosporine-Induced Apoptosis.

Chemistry & biology·2015
Same journal

Synthetic Peptides as cGMP-Independent Activators of cGMP-Dependent Protein Kinase Iα.

Chemistry & biology·2015
Same journal

Unraveling the B. pseudomallei Heptokinase WcbL: From Structure to Drug Discovery.

Chemistry & biology·2015
Same journal

Vitamin C as Cancer Destroyer, Investigating Sulfhydration, and the Variability in CFTR Interactome.

Chemistry & biology·2015
See all related articles

Related Experiment Video

Updated: Jun 16, 2026

Co-localizing Kelvin Probe Force Microscopy with Other Microscopies and Spectroscopies: Selected Applications in Corrosion Characterization of Alloys
12:18

Co-localizing Kelvin Probe Force Microscopy with Other Microscopies and Spectroscopies: Selected Applications in Corrosion Characterization of Alloys

Published on: June 27, 2022

A tale of two metals.

Ninian J Blackburn1

  • 1Department of Science and Engineering, School of Medicine, Oregon Health & Sciences University, 20000 NW Walker Road, Beaverton, OR 97006-8291, USA.

Chemistry & Biology
|February 10, 2010
PubMed
Summary
This summary is machine-generated.

Tetrathiomolybdate inhibits copper proteins by forming metal clusters. This finding explains the long-known antagonistic effects between molybdenum (Mo) and copper (Cu) in biological systems.

More Related Videos

Clean Sampling and Analysis of River and Estuarine Waters for Trace Metal Studies
10:44

Clean Sampling and Analysis of River and Estuarine Waters for Trace Metal Studies

Published on: July 1, 2016

Rearing the Cabbage White Butterfly (Pieris rapae) in Controlled Conditions: A Case Study with Heavy Metal Tolerance
08:08

Rearing the Cabbage White Butterfly (Pieris rapae) in Controlled Conditions: A Case Study with Heavy Metal Tolerance

Published on: August 18, 2023

Related Experiment Videos

Last Updated: Jun 16, 2026

Co-localizing Kelvin Probe Force Microscopy with Other Microscopies and Spectroscopies: Selected Applications in Corrosion Characterization of Alloys
12:18

Co-localizing Kelvin Probe Force Microscopy with Other Microscopies and Spectroscopies: Selected Applications in Corrosion Characterization of Alloys

Published on: June 27, 2022

Clean Sampling and Analysis of River and Estuarine Waters for Trace Metal Studies
10:44

Clean Sampling and Analysis of River and Estuarine Waters for Trace Metal Studies

Published on: July 1, 2016

Rearing the Cabbage White Butterfly (Pieris rapae) in Controlled Conditions: A Case Study with Heavy Metal Tolerance
08:08

Rearing the Cabbage White Butterfly (Pieris rapae) in Controlled Conditions: A Case Study with Heavy Metal Tolerance

Published on: August 18, 2023

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Toxicology

Background:

  • Copper (Cu) and Molybdenum (Mo) exhibit antagonistic effects in biological systems, a phenomenon recognized but poorly understood.
  • Copper-trafficking proteins are crucial for various physiological processes, and their dysregulation can lead to disease.

Purpose of the Study:

  • To elucidate the mechanism by which tetrathiomolybdate inhibits copper-trafficking proteins.
  • To provide a molecular explanation for the antagonistic interactions between molybdenum and copper.

Main Methods:

  • The study involved investigating the interaction between tetrathiomolybdate and copper-trafficking proteins.
  • Metal cluster formation was analyzed as a key mechanism.

Main Results:

  • Tetrathiomolybdate was shown to inhibit copper-trafficking proteins through the formation of metal clusters.
  • This metal cluster formation disrupts the normal function of copper transport.

Conclusions:

  • The formation of metal clusters by tetrathiomolybdate is the mechanism underlying its inhibition of copper-trafficking proteins.
  • This provides a molecular basis for the antagonistic effects of molybdenum and copper in living organisms.