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Related Concept Videos

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...

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Updated: Jun 16, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Heart involvement in systemic sclerosis: evolving concept and diagnostic methodologies.

Christophe Meune1, Olivier Vignaux, André Kahan

  • 1Service de cardiologie, hôpital Cochin, AP-HP, université Paris Descartes, 27, rue du Faubourg-Saint-Jacques, 75014 Paris, France. christophe.meune@cch.aphp.fr

Archives of Cardiovascular Diseases
|February 10, 2010
PubMed
Summary
This summary is machine-generated.

Systemic sclerosis frequently causes heart problems, leading to fibrosis. Early detection through advanced imaging and biomarkers like B-type natriuretic peptides is crucial for better patient outcomes.

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Last Updated: Jun 16, 2026

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Vasodilation of Isolated Vessels and the Isolation of the Extracellular Matrix of Tight-skin Mice

Published on: March 24, 2017

Area of Science:

  • Cardiology
  • Rheumatology
  • Medical Imaging

Background:

  • Heart involvement, particularly primary myocardial issues, is prevalent in systemic sclerosis.
  • This cardiac involvement is linked to repeated focal ischemic injury, resulting in irreversible myocardial fibrosis.
  • Clinically apparent cardiac issues indicate a poor prognosis, underscoring the need for early detection.

Purpose of the Study:

  • To highlight the commonality and severity of cardiac involvement in systemic sclerosis.
  • To emphasize the importance of preclinical identification of heart involvement.
  • To review current and advanced diagnostic modalities for assessing cardiac function and structure.

Main Methods:

  • Echocardiography, including pulsed tissue Doppler echocardiography, is the standard for cardiac assessment.
  • Single photon emission computed tomography (SPECT) can evaluate myocardial perfusion.
  • Cardiac magnetic resonance imaging (CMR) offers comprehensive assessment of volumes, function, perfusion, inflammation, and fibrosis.

Main Results:

  • Systemic sclerosis commonly affects the heart, leading to myocardial fibrosis via ischemic injury.
  • Advanced imaging techniques like echocardiography, SPECT, and CMR are vital for detailed cardiac evaluation.
  • Biomarkers such as B-type natriuretic peptides are valuable indicators of global heart involvement.

Conclusions:

  • Early and accurate detection of cardiac involvement in systemic sclerosis is critical due to its poor prognostic implications.
  • A multimodal approach combining imaging (echocardiography, CMR) and biomarkers (BNP) is recommended for comprehensive patient assessment.
  • These methods aid in screening patients and advancing research on systemic sclerosis-related heart disease.