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Updated: Jun 16, 2026

Surgical Porcine Model of Chronic Myocardial Ischemia Treated by Exosome-laden Collagen Patch and Off-pump Coronary Artery Bypass Graft
Published on: September 15, 2023
How should I treat a complex Post-CABG patient?
Giovanna Sarno1, Carl Schultz, Scot Garg
1Department of Cardiology, Erasmus MC, Thoraxcenter, Rotterdam, The Netherlands.
This case study highlights a patient with unstable angina and complex coronary artery disease, including occluded grafts and diffuse lesions. Revascularization was performed to address critical blockages in the coronary arteries.
Area of Science:
- Cardiology
- Interventional Cardiology
- Vascular Biology
Background:
- A 69-year-old male presented with unstable angina (Class IIB).
- Significant past medical history includes chronic renal impairment, diabetes mellitus, and hypertension.
- Previous coronary artery bypass surgery in 1997 utilized left internal mammary artery (LIMA) and saphenous vein grafts.
Observation:
- Coronary angiography revealed occlusion of the left circumflex (LCx) and right coronary arteries (RCA).
- The LIMA grafts to the left anterior descending (LAD) and diagonal branches were functionally occluded.
- Diffuse disease of the LAD was noted, with two significant stenotic lesions.
Findings:
- Critical stenoses in the LAD and its branches, alongside occluded native vessels and bypass grafts.
- Complex coronary artery disease necessitating intervention.
Implications:
- Successful revascularization is crucial for managing unstable angina in patients with complex coronary artery disease.
- This case underscores the challenges in managing patients with prior bypass surgery and diffuse coronary pathology.
- Optimal medical management and timely revascularization strategies are vital for improving outcomes in such high-risk patients.
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