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Related Experiment Video

Updated: Jun 16, 2026

Quantitative Proteomics Workflow using Multiple Reaction Monitoring Based Detection of Proteins from Human Brain Tissue
11:49

Quantitative Proteomics Workflow using Multiple Reaction Monitoring Based Detection of Proteins from Human Brain Tissue

Published on: August 28, 2021

Proteomic research in psychiatry.

Regina Taurines1, Edward Dudley, Julia Grassl

  • 1Academic Unit of Psychiatry, The School of Medicine, Institute of Life Science, Swansea University, Singleton Park, Swansea SA2 8PP, UK.

Journal of Psychopharmacology (Oxford, England)
|February 10, 2010
PubMed
Summary

Proteomics, the study of proteins, offers new ways to understand complex psychiatric disorders like Alzheimer's disease and schizophrenia. This technology helps identify biomarkers for better diagnosis and treatment of these challenging conditions.

Related Concept Videos

Proteomics01:33

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...

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Area of Science:

  • Neuroscience
  • Biochemistry
  • Psychiatry

Background:

  • Psychiatric disorders present diagnostic and treatment challenges due to unknown origins and heterogeneity.
  • Current understanding of pathophysiology is limited, hindering effective interventions.

Purpose of the Study:

  • To review the role of proteomics in psychiatric research.
  • To discuss the application of proteomic technologies in understanding neuropsychiatric disorders.
  • To highlight the potential of proteomics for biomarker discovery.

Main Methods:

  • Review of theoretical background and techniques in proteomics, particularly mass spectrometry.
  • Analysis of current proteomic research in various psychiatric conditions.
  • Emphasis on protein expression levels, post-translational modifications, and interaction networks.

Related Experiment Videos

Last Updated: Jun 16, 2026

Quantitative Proteomics Workflow using Multiple Reaction Monitoring Based Detection of Proteins from Human Brain Tissue
11:49

Quantitative Proteomics Workflow using Multiple Reaction Monitoring Based Detection of Proteins from Human Brain Tissue

Published on: August 28, 2021

Main Results:

  • Proteomics enables high-throughput protein determination, offering insights beyond genetic analysis.
  • Proteomic approaches can reveal protein modifications directly linked to disease pathophysiology.
  • Significant impact of proteomic research is evident across Alzheimer's disease, schizophrenia, mood disorders, and autism.

Conclusions:

  • Proteomics provides a powerful tool for unraveling the molecular basis of psychiatric disorders.
  • Proteomic methods are crucial for identifying diagnostic and prognostic biomarkers.
  • The significance of proteomics in psychiatric research and neuropharmacology is expected to grow substantially.